Effect of the sulfonylurea glyburide on superoxide dismutase in streptozotocin-induced diabetic rat muscle
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Open Access Color
Green Open Access
Yes
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No
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Top 10%
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Top 10%
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Average
Abstract
1. The effect of glyburide (glibenclamide) treatment on the muscle superoxide dismutase (SOD) activity of diabetic rats has been studied. 2. Four weeks of treatment with glyburide (5 mg/kg, orally) increased muscle SOD activity and decreased blood glucose levels. 3. The results of this study demonstrate that the sulfonylurea, glyburide, is capable of exerting direct insulinlike effects on muscle SOD activity in vivo.
Description
Keywords
diabetes mellitus, Glyburide, superoxide dismutase, glibenclamide, glucose, streptozocin, sulfonylurea derivative, animal model, animal tissue, article, controlled study, drug effect, enzyme activity, glucose blood level, male, muscle, nonhuman, oral drug administration, priority journal, rat, streptozocin diabetes, Animals, Blood Glucose, Body Weight, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Hypoglycemic Agents, Male, Muscle, Skeletal, Rats, Superoxide Dismutase, Blood Glucose, Male, muscle, oral drug administration, animal tissue, Diabetes Mellitus, Experimental, Experimental, male, Glyburide, Animals, Hypoglycemic Agents, controlled study, rat, glucose, Muscle, Skeletal, nonhuman, Superoxide Dismutase, streptozocin, animal model, drug effect, Body Weight, article, Skeletal, superoxide dismutase, 620, enzyme activity, Rats, glucose blood level, priority journal, Diabetes Mellitus, Type 2, glibenclamide, diabetes mellitus, sulfonylurea derivative, streptozocin diabetes, Muscle, Type 2
Fields of Science
0301 basic medicine, 03 medical and health sciences, 0303 health sciences
Citation
WoS Q
Scopus Q
OpenCitations Citation Count
12
Source
Volume
28
Issue
5
Start Page
795
End Page
796
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CrossRef : 7
Scopus : 17
PubMed : 2
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Mendeley Readers : 11
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17
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Web of Science™ Citations
14
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61
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