Association of synapsin III gene with adult attention deficit hyperactivity disorder
Association of synapsin III gene with adult attention deficit hyperactivity disorder
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Abstract
It was aimed to investigate the association of the synapsin III gene -196 G> A and -631 C>G polymorphisms that takes place in an encoding presynaptic protein, with adult attention deficit hyperactivity disorder (ADHD). One hundred thirty-nine patients having adult ADHD and 106 controls were included in the study. DNA samples were extracted from whole blood and genetic analyses were performed. A significant difference was determined between ADHD and synapsin III gene -631 C>G polymorphism compared to the control group. No significant difference was determined between ADHD and synapsin III gene -196 G>A polymorphism. These polymorphisms were found not to be associated with subtypes of ADHD. It is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of ADHD. © Copyright 2013, Mary Ann Liebert, Inc. 2013.
Description
Keywords
genomic DNA, phosphoprotein, synapsin III, unclassified drug, adult, adult disease, allele, article, attention deficit disorder, comparative study, controlled study, DNA polymorphism, female, gene frequency, genetic analysis, genetic association, genotype, human, major clinical study, male, priority journal, Adult, Age of Onset, Alleles, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Humans, Male, Polymorphism, Single Nucleotide, Synapsins, Young Adult, Adult, Male, genomic DNA, genetic association, genotype, attention deficit disorder, 610, genetic analysis, gene frequency, Polymorphism, Single Nucleotide, Hyperactivity disorder, Young Adult, male, Gene Frequency, Humans, controlled study, Genetic Predisposition to Disease, human, Polymorphism, Age of Onset, comparative study, Alleles, Genetic Association Studies, adult, allele, article, Single Nucleotide, phosphoprotein, Synapsins, major clinical study, unclassified drug, female, priority journal, DNA polymorphism, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, Female, synapsin III, adult disease, Synapsin III Gene, Adult attention deficit hyperactivity disorder
Fields of Science
03 medical and health sciences, 0302 clinical medicine
Citation
WoS Q
Scopus Q
OpenCitations Citation Count
16
Source
Volume
32
Issue
8
Start Page
430
End Page
434
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