Tıp Fakültesi Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11499/46004
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Article Aesthetic Interventions in Patients with Allergic Skin Diseases: Risk Assessment and Evidence-Based Preventive Risk Management(Elsevier Inc., 2026-03) Yiğit, İçim Kömürcügil; Türsen, Ümit; Türsen, Belma; Solak, Berna; Bakay, Özge Sevil Karstarlı; Kroumpouzos, GeorgeArticle Probiotics for Skin Aging and Skin Conditions in the Elderly(Elsevier Inc., 2026-02) Yiğit, İçim Kömürcügil; Türsen, Ümit; Türsen, Belma; Solak, Berna; Bakay, Özge Sevil Karstarlı; Kroumpouzos, GeorgeArticle Tideglusib Accelerates Bone-Tendon Interface Healing and Improves Mechanical Strength in a Rabbit Rotator Cuff Tear Model: An Experimental Study(BMC, 2026-02-14) Ocaklar, Zeynel Can; Unal, Murat Serkant; Yorukoglu, A. CagdasBackground The present study aimed to investigate the effects of the glycogen synthase kinase-3 (GSK-3) inhibitor tideglusib on bone-tendon interface healing in a rabbit model of rotator cuff injury, based on biomechanical and histological assessments. Methods Fourteen New Zealand rabbits underwent supraspinatus tendon detachment to establish a chronic rotator cuff tear model. After six weeks, surgical repair was performed. In the right shoulders, tideglusib was administered at the bone-tendon junction prior to performing the primary repair (drug group), whereas the left shoulders underwent primary repair without biological augmentation (control group). Seven animals were included in the group subjected to biomechanical tension testing, and six for histological evaluation. Results Biomechanical evaluation demonstrated that the tideglusib group showed significantly higher load-to-failure values compared with the control group the control group (p < 0.05), whereas elongation at failure showed no statistically significant difference. Histological scoring demonstrated significantly improved cellular organization and tissue healing in the tideglusib group (p < 0.05). Conclusion Local application of tideglusib positively enhances tendon-bone healing both biomechanically and histologically. Further studies are warranted to explore its potential clinical applications.Article The Time-Dependent Effects of Temozolomide on Autophagy Gene Expression in Glioblastoma Cells(MDPI, 2026-03-13) Kiraz, Ilker; Aydin, Veli Kaan; Kurt, Ozgur; Coskun, Mehmet Erdal; Lengerova, Gergana; Bozhkova, Martina; Petrov, Steliyan; Koseler, AylinBackground: Temozolomide (TMZ) resistance represents a major therapeutic challenge in glioblastoma treatment, where autophagy has emerged as a key adaptive survival mechanism. Although numerous studies have implicated autophagy in TMZ resistance, most have assessed this process at a single point, thereby overlooking its dynamic and time-dependent nature. Methods: In this study, we systematically investigated the temporal regulation of autophagy-related gene expression in two human glioblastoma cell lines with distinct MGMT methylation status and TMZ sensitivities (T98G and U87) following TMZ treatment. Cells were exposed to TMZ and harvested at defined time points (0 h, 6 h, 24 h, and 48 h). The expression levels of genes representing distinct stages of the autophagy pathway, including initiation, nucleation, elongation, selective autophagy, lysosomal function, and transcriptional regulation, were analyzed using RT-qPCR. Relative gene expression was calculated using the 2-Delta Delta CT method with GAPDH as the reference gene. Results: Our results reveal a time-dependent and phase-specific transcriptional reprogramming of the autophagy machinery in response to TMZ-induced stress. Early time points were characterized by modulation of autophagy initiation and nucleation genes, whereas intermediate and late phases showed prominent regulation of genes associated with autophagosome elongation, selective autophagy, autophagic flux, and transcriptional control. Conclusions: Collectively, these findings demonstrate that autophagy in TMZ-treated glioblastoma cells is not a static response but a dynamically regulated, multi-phase program. Specifically, in TMZ-resistant T98G cells, this process matures into a sustained adaptive program with robust late-phase lysosomal integration, while in TMZ-sensitive U87 cells, the early autophagic response is transient and fails to support long-term lysosomal coordination. This temporal perspective provides new insights into the role of autophagy in TMZ tolerance and underscores the importance of time-resolved analyses when targeting autophagy to overcome chemoresistance in glioblastoma.Article Tetik parmak cerrahisi yapılan hastaların demografik özellikleri(2026-01-01) Aydemir, Ahmet; Tütüncüler, ErmanAim: This study aimed to evaluate the demographic characteristics of patients who underwent surgical treatment for trigger finger and to compare the findings with the literature. Materials and Methods: Following the approval of the Pamukkale University Non-Interventional Clinical Research Ethics Committee (Approval No: E-60116787-020-610909; Date: 15 November 2024), medical records of patients who underwent trigger finger surgery between 2023 and 2024 were retrospectively reviewed. Demographic data including age, sex, affected hand (right or left), and operated finger were collected. Statistical analyses were performed using the chi-square goodness-of-fit test and independent samples t-test. Results: A total of 582 patients (473 females, 109 males) underwent open A1 pulley release for trigger finger. Female predominance was statistically significant (p = 1.93 × 10⁻⁵¹). The mean age was 55.61 years for females and 52.53 years for males (p = 0.049). The right hand was affected more frequently than the left (56.5% vs. 43.5%; p = 0.0017). The most commonly operated finger was the thumb, followed by the third and fourth fingers (p < 0.001). Conclusion: Trigger finger was found to be more common in middle-aged and elderly women, with the right hand and thumb being most frequently affected. Dominant hand use and repetitive strain may play a role in the higher incidence of thumb involvement. These findings are consistent with the literature and provide regional demographic insight into surgically treated trigger finger cases.Article The Academic Hunger Gap: From Plates to Well-Being-How Food Insecurity Undermines Quality of Life in University Students(Wiley, 2026-03) Kandemir, Ummuhan Inci; Uzun, Suleyman UtkuFood insecurity, a significant global challenge, is increasingly recognized among university students, potentially impacting their quality of life (QoL). This study aimed to assess the prevalence of food insecurity and its association with QoL among university students in Denizli, Türkiye. A cross-sectional study was conducted among 1495 university students. Food insecurity was assessed using the Household Food Insecurity Access Scale (HFIAS), categorized as food secure, mild, moderate, or severe insecurity. Quality of life was measured with the SF-12, yielding Physical Component Summary (PCS) and Mental Component Summary (MCS) scores. Multiple linear regression analyses were performed to identify predictors of physical (PCS) and mental (MCS) components of quality of life. The prevalence of food insecurity was 44.9%, with 20.9% experiencing mild, 16.0% moderate, and 8.0% severe food insecurity. Food-insecure students had significantly lower PCS (50.16 +/- 8.05 vs. 52.50 +/- 6.89, p < 0.001) and MCS scores (38.24 +/- 10.30 vs. 41.58 +/- 10.28, p < 0.001) compared to food-secure students. A dose-response was observed; increasing food insecurity severity correlated with decreasing PCS and MCS scores (p < 0.001 for both). In multivariable models, food insecurity remained an independent negative predictor of PCS and MCS, alongside other factors such as income, chronic disease, smoking, and gender. Food insecurity affects nearly half of university students and is significantly associated with poorer physical and mental quality of life, even after controlling for various confounding factors. These findings highlight the urgent need for targeted university interventions including campus food assistance programs, enhanced financial aid policies to address food insecurity and improve student well-being.Article Synthesis and Comparative Biological Analysis of Mixed NHC/L Platinum (II) Complexes: Anticancer and Antimicrobial Properties(Elsevier B.V., 2026-08) Aslan, Sümeyye; Bugday, Nesrin; Boulebd, Houssem; Yüce, Hande; Türkmen, Neşe Başak; Özek, Dilan Aşkın; Günal, Selami ; Berberoğlu, Yasemin; Eke, Benay Can; Yaşar, Sedat; Ünüvar, SongülPlatinum-N-heterocyclic carbene (Pt-NHC) complexes have garnered significant interest as potential anticancer agents, with their efficacy influenced by their structural characteristics and ligand environments. In this study, eight of Pt-NHC complexes were synthesized via a one-pot synthesis method from related NHC precursors, which have different electronic and steric properties, and fully characterized by (1H and 13C) NMR, HRMS, FT-IR spectroscopy, and elemental analysis. Their anticancer and antimicrobial properties were evaluated by investigating cytotoxicity, inhibition of cancer cell migration, antimicrobial and antifungal activities, and apoptotic effects. The Pt-NHC complexes demonstrated notable antiproliferative and anti-migratory effects against SHSY5Y (human neuroblastoma), A549 (human lung cancer), MDA-MB-231 (human breast cancer), and HeLa (human cervical cancer) cell lines, as well as significant antimicrobial activity against S. aureus, C. albicans, and MRSA strains. Molecular docking analyses were performed to explore interactions between the complexes and cancer cell targets. Variation in the Bax/Bcl-2 ratio highlighted differences in apoptotic regulation across cancer cell lines. Notably, the Pt-NHC complexes exhibited greater efficacy than cisplatin, underscoring their promise as candidates for drug development, although further investigation into the complex roles of Bax and Bcl-2 in apoptosis is needed for a comprehensive evaluation of these new therapeutic agents.Article Slow-Releasing CO Donor CORM-A1 Modulates Depression-like Behavior in Experimental Model of Chronic Prostatitis/Chronic Pelvic Pain Syndrome(Nencki Institute of Experimental Biology, 2026-02-20) Šutulović, Nikola; Ezgin, Neriman; Djurić, Emilija; Grubač, Željko; Vesković, Milena; Mladenović, Dušan; Dodurga, Yavuz; Marković, Aleksandra Rašić; Stanojlović, Olivera; Hrnčić, DraganArticle Silent Hunger: Unveiling Food Insecurity among University Students in Türkiye(Emerald Group Publishing Ltd, 2026-03-20) Uzun, Suleyman Utku; Kandemir, Ummuhan InciPurposeFood insecurity is a global public health concern with profound implications for physical health, mental well-being and academic performance. University students are disproportionately affected, with limited research available in Türkiye. This study investigates the prevalence and determinants of food insecurity among students at Pamukkale University in Denizli, Türkiye.Design/methodology/approachA cross-sectional study was conducted between December 1 and December 20, 2023, among 649 students selected through stratified random sampling. Data were collected via face-to-face surveys using a structured questionnaire that included the 9-item Household Food Insecurity Access Scale Logistic regression analysis identified factors associated with food insecurity.FindingsThe prevalence of food insecurity among participants was 41.9%, with 23.0% reporting mild, 14.2% moderate and 4.8% severe food insecurity. Factors significantly associated with food insecurity included insufficient income and debt (OR = 4.268, 95% CI: 2.505-7.273), insufficient income without debt (OR = 2.293, 95% CI: 1.379-3.815) and sufficient income but no savings (OR = 1.589, 95% CI: 1.032-2.446). Students living in dormitories or apartments were more likely to experience food insecurity compared to those living with family (OR = 3.050, 95% CI: 2.074-4.484).Originality/valueFood insecurity is a significant issue among the surveyed student population in Denizli, Türkiye, driven by financial constraints and living arrangements. Addressing this issue requires systemic interventions, including increased financial support, affordable housing and targeted programs. Ensuring food security among students is essential for fostering their academic success and overall well-being.Letter Response to Comment ‘Comment on “The Effects of Early Rehabilitation on Physical and Psychosocial Functions after Breast Cancer Surgery”’(Springer, 2026-03-13) Özdemir, Atiye Kaş; Atalay, Orçin Telli; Yılmaz, Sevda; Şenol, Hande