L-Phenylalanine-Imprinted Electrochemical Sensor Based on WS2 Nanoflowers on N,B-Doped Graphene and Its Application to Milk Samples
L-Phenylalanine-Imprinted Electrochemical Sensor Based on WS2 Nanoflowers on N,B-Doped Graphene and Its Application to Milk Samples
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Abstract
Phenylketonuria (PKU) is a critical disease in the disorder of amino acid metabolism, which mostly emerges in children. The most common method used in PKU treatment is the detection of L-phenylalanine (PHEA) as the biomarker of PKU. In the present work, a new molecularly imprinted electrochemical electrode based on WS2 nanoflowers (NFs) on N,B-doped graphene (WS2 NFs/N,B-GR) is presented for PHEA assay in milk samples. First of all, WS2 NFs/N,B-GR was synthesized via a high-efficiency hydrothermal synthesis. Cyclic voltammetry was applied to the electrochemical cell, including PHEA as a template molecule and pyrrole as a monomer, to form PHEA-imprinted electrochemical electrodes. Then, the structural and morphological features of WS2 NFs and WS2 NFs/N,B-GR were investigated in detail by various analytical methods. The limit of quantification and limit of detection values were obtained as 1.0 × 10-11 and 3.0 × 10-12 M, respectively, by a PHEA-imprinted electrochemical electrode. Finally, a PHEA-imprinted electrochemical sensor having a high degree of selectivity, stability, and reusability is presented in the literature for early diagnosis of PKU. © 2022 American Chemical Society. All rights reserved.
Description
Keywords
Amino acids, Cyclic voltammetry, Diagnosis, Electrochemical sensors, Graphene, Hydrothermal synthesis, Nanoflowers, Reusability, Tungsten compounds, Amino acid metabolism, Analytical method, Higher efficiency, ITS applications, Milk sample, Molecularly imprinted, Morphological features, Structural feature, Synthesised, Template molecules, Electrochemical electrodes, Synthesised, Cyclic voltammetry, diagnosis, Molecularly imprinted, Higher efficiency, amino acid metabolism, Amino acid metabolism, Analytical method, Template molecules, Diagnosis, ITS applications, Electrochemical sensors, Hydrothermal synthesis, tungsten compounds, Reusability, amino acids, Morphological features, graphene, Nanoflowers, electrochemical sensors, nanoflowers, 540, Milk sample, cyclic voltammetry, Electrochemical electrodes, hydrothermal synthesis, reusability, Amino acids, Tungsten compounds, Graphene, Structural feature
Fields of Science
02 engineering and technology, 01 natural sciences, 0104 chemical sciences, 0210 nano-technology
Citation
WoS Q
Scopus Q
OpenCitations Citation Count
43
Volume
62
Issue
11
Start Page
4587
End Page
4594
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