MEFV Gene Mutation Frequency and Correlation of Mutations with Clinical Symptoms in Gout

Abstract

Gout is a clinical syndrome that occurs as an inflammatory response to increased concentration of uric acid and monosodium urate crystals. IL – 1B is the most important cytokine in gout pathogenesis. Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease with autosomal recessive inheritance.