Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10010
Title: Glomerular and tubular functions in children with different forms of beta thalassemia
Authors: Uzun, Ebru
Balcı, Yasemin Işık
Yüksel, Selçuk
Aral, Y.Z.
Aybek, Hülya
Akdağ, Beyza
Keywords: Alpha-1 macroglobulin
Cystatin C
Hemoglobinopathies
Renal function
Retinol-binding protein
alpha 1 macroglobulin
beta 2 microglobulin
calcium
creatinine
cystatin C
deferasirox
ferritin
hemoglobin
macroglobulin
phosphorus
protein
retinol binding protein
unclassified drug
uric acid
alpha 2 macroglobulin
sodium
Article
calcium urine level
case control study
child
childhood disease
controlled study
creatinine blood level
creatinine clearance
female
ferritin blood level
glomerulus filtration rate
groups by age
hemoglobin blood level
human
kidney tubule absorption
kidney tubule function
major clinical study
male
priority journal
prospective study
protein urine level
school child
sodium excretion
thalassemia intermedia
thalassemia major
thalassemia minor
uric acid urine level
urinary excretion
adolescent
beta thalassemia
blood
classification
metabolism
nephron
pathophysiology
urine
Adolescent
alpha-Macroglobulins
beta 2-Microglobulin
beta-Thalassemia
Case-Control Studies
Child
Creatinine
Female
Glomerular Filtration Rate
Humans
Male
Nephrons
Prospective Studies
Retinol-Binding Proteins
Sodium
Uric Acid
Publisher: Taylor and Francis Ltd
Abstract: Background: Although there are many available data about renal involvement in patients with beta thalassemia major (TM), the changes in renal functions of other types, such as thalassemia intermedia (TI) and thalassemia minor (TMin), were reported less. Therefore, we aimed to evaluate renal tubular and glomerular functions in patients with three types of beta thalassemia. Methods: This prospective case-control study was conducted on 118 beta-thalassemia patients (49 in TM, 18 in TI and 51 TMin) and 51 healthy controls. Glomerular functions [estimated glomerular filtration rate (GFR), serum cystatin C and urinary protein creatinine ratio] and tubular functions [fractioned sodium excretion (FENa), tubular reabsorption of phosphorus, urinary excretion of uric acid, levels of retinol-binding protein, alpha-1 macroglobulin (alpha-1M), and beta-2 microglobulin, calcium creatinine ratio] were assessed in all patients and controls. Results: The mean ages of the groups and controls at presentation were similar. Although GFR was similar in all patients and control groups, serum levels of cystatin C in patients with TM and TI were significantly higher compared to TMin and controls. Alpha-1M, FENa, urinary excretion of uric acid, and urine protein/creatinine ratio in TM and TI groups were significantly higher than the others. Mean cystatin C level was also higher in patients with TMin compared the controls. However, there were no significant differences according to all tubular and other glomerular functions between TMin and control groups. Conclusions: Although all types of beta thalassemia patients should be closely monitored to prevent further decrease in renal functions, the patients with TI should be considered to have a higher risk of glomerular and tubular deterioration as well as TM. © 2015 © 2015 Taylor & Francis.
URI: https://hdl.handle.net/11499/10010
https://doi.org/10.3109/0886022X.2015.1077314
ISSN: 0886-022X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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