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https://hdl.handle.net/11499/10037
Title: | Association of adult attention deficit hyperactivity disorder subtypes and response to methylphenidate HCL treatment: A magnetic resonance spectroscopy study | Authors: | Ünal, Gonca Ayşe Kenar, Ayşe Nur İnci Herken, Hasan Kıroğlu, Yılmaz |
Keywords: | Adult ADHD Magnetic resonance spectroscopy Methylphenidate Subtype choline creatine methylphenidate n acetylaspartic acid aspartic acid central stimulant agent N-acetylaspartate adult anterior cingulate Article attention deficit disorder cerebellum corpus striatum dorsolateral prefrontal cortex drug effect female human major clinical study male metabolite nuclear magnetic resonance scanner nuclear magnetic resonance spectroscopy priority journal treatment response adolescent analogs and derivatives Attention Deficit Disorder with Hyperactivity cingulate gyrus metabolism middle aged prefrontal cortex young adult Adolescent Adult Aspartic Acid Central Nervous System Stimulants Cerebellum Choline Corpus Striatum Creatine Female Gyrus Cinguli Humans Magnetic Resonance Spectroscopy Male Middle Aged Prefrontal Cortex Young Adult |
Publisher: | Elsevier Ireland Ltd | Abstract: | The effects of methylphenidate (MPH) treatment on N-acetyl aspartate (NAA), choline and creatine are being examined in individuals with different subtypes of attention deficit hyperactivity disorder (ADHD). Sixty ADHD subjects were included into the study aging between 18 and 60 years. Levels of NAA, creatine and choline in anterior cingulate cortex, cerebellum, striatum and dorsolateral prefrontal cortex were measured with magnetic resonance spectroscopy. Then, 10 mg oral MPH was given to the subjects and the same metabolite levels were measured after an interval of 30 min. Distribution of the patients according to the ADHD subtypes was as follows: 21 of them (35.0%) were in the inattentive type, 11 of them (18.3%) were in the hyperactive type and 28 of them were (46.7%) in the combined type. Changes of brain metabolite levels after MPH were found not to be statistically significantly different between the subtypes. The increase of choline levels after MPH compared to the levels of choline before MPH in striatum in the combined type patients were statistically significant. No clear association was found between ADHD subtypes and changes of brain metabolites with use of MPH in adult ADHD. © 2015 Elsevier Ireland Ltd. | URI: | https://hdl.handle.net/11499/10037 https://doi.org/10.1016/j.neulet.2015.08.006 |
ISSN: | 0304-3940 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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