Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10037
Title: Association of adult attention deficit hyperactivity disorder subtypes and response to methylphenidate HCL treatment: A magnetic resonance spectroscopy study
Authors: Ünal, Gonca Ayşe
Kenar, Ayşe Nur İnci
Herken, Hasan
Kıroğlu, Yılmaz
Keywords: Adult ADHD
Magnetic resonance spectroscopy
Methylphenidate
Subtype
choline
creatine
methylphenidate
n acetylaspartic acid
aspartic acid
central stimulant agent
N-acetylaspartate
adult
anterior cingulate
Article
attention deficit disorder
cerebellum
corpus striatum
dorsolateral prefrontal cortex
drug effect
female
human
major clinical study
male
metabolite
nuclear magnetic resonance scanner
nuclear magnetic resonance spectroscopy
priority journal
treatment response
adolescent
analogs and derivatives
Attention Deficit Disorder with Hyperactivity
cingulate gyrus
metabolism
middle aged
prefrontal cortex
young adult
Adolescent
Adult
Aspartic Acid
Central Nervous System Stimulants
Cerebellum
Choline
Corpus Striatum
Creatine
Female
Gyrus Cinguli
Humans
Magnetic Resonance Spectroscopy
Male
Middle Aged
Prefrontal Cortex
Young Adult
Publisher: Elsevier Ireland Ltd
Abstract: The effects of methylphenidate (MPH) treatment on N-acetyl aspartate (NAA), choline and creatine are being examined in individuals with different subtypes of attention deficit hyperactivity disorder (ADHD). Sixty ADHD subjects were included into the study aging between 18 and 60 years. Levels of NAA, creatine and choline in anterior cingulate cortex, cerebellum, striatum and dorsolateral prefrontal cortex were measured with magnetic resonance spectroscopy. Then, 10 mg oral MPH was given to the subjects and the same metabolite levels were measured after an interval of 30 min. Distribution of the patients according to the ADHD subtypes was as follows: 21 of them (35.0%) were in the inattentive type, 11 of them (18.3%) were in the hyperactive type and 28 of them were (46.7%) in the combined type. Changes of brain metabolite levels after MPH were found not to be statistically significantly different between the subtypes. The increase of choline levels after MPH compared to the levels of choline before MPH in striatum in the combined type patients were statistically significant. No clear association was found between ADHD subtypes and changes of brain metabolites with use of MPH in adult ADHD. © 2015 Elsevier Ireland Ltd.
URI: https://hdl.handle.net/11499/10037
https://doi.org/10.1016/j.neulet.2015.08.006
ISSN: 0304-3940
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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