Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10104
Title: Could serum pentraxin 3 levels and IgM deposition in skin biopsies predict subsequent renal involvement in children with Henoch–Schönlein purpura?
Authors: Yüksel, Selçuk
Çağlar, Murat
Evrengül, Havva
Becerir, Tülay
Tepeli, Emre
Ergin, Ahmet
Avcı Çiçek, Esin
Keywords: Early predictor
Henoch–Schönlein purpura
Nephritis
Pentraxin 3
Vasculitis
biological marker
C reactive protein
immunoglobulin M
pentraxin 3
serum amyloid P
adolescent
biopsy
blood
case control study
child
complication
disease course
enzyme linked immunosorbent assay
evaluation study
female
fluorescent antibody technique
human
immunology
male
nephritis
predictive value
preschool child
prognosis
prospective study
Purpura, Schoenlein-Henoch
skin
time
upregulation
Adolescent
Biomarkers
Biopsy
C-Reactive Protein
Case-Control Studies
Child
Child, Preschool
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique
Humans
Immunoglobulin M
Male
Predictive Value of Tests
Prognosis
Prospective Studies
Serum Amyloid P-Component
Skin
Time Factors
Up-Regulation
Publisher: Springer Verlag
Abstract: Background: The aim of this study was to evaluate the potential of serum pentraxin 3 (PTX3) values as an early predictor of subsequent renal involvement in patients with Henoch–Schönlein purpura (HSP) with no abnormalities on urinary examination and in renal function tests at disease onset. Methods: This was a prospective cohort study which included 60 pediatric patients with HSP (age range 3–15 years) who were diagnosed between February 2011 and October 2012 and 60 age- and sex-matched healthy controls. The patients were followed up for at least 18 months. Clinical findings were recorded for all patients at first examination, and blood samples for routine laboratory parameters and PTX3 value as well as skin biopsy specimens were obtained from each subject. Results: Of the 60 patients with HSP, 29 (48.3 %) developed subsequent renal involvement, of whom four underwent kidney biopsy. The mean serum PTX3 level of patients with subsequent renal involvement was significantly higher than those of patients without renal involvement and of the controls (2.20 ± 1.30 vs. 1.36 ± 0.85 and 1.03 ± 0.7 ng/ml, respectively; p = 0.004). Immunofluorescence evaluation of skin biopsy revealed that in addition to immunoglobulin A (IgA) deposition, the IgM deposition was significantly associated with subsequent renal involvement (p = 0.008). Conclusions: A high PTX3 level and IgM staining in skin biopsies from HSP patients may be harbingers of subsequent renal involvement. © 2014, IPNA.
URI: https://hdl.handle.net/11499/10104
https://doi.org/10.1007/s00467-014-3026-x
ISSN: 0931-041X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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