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https://hdl.handle.net/11499/10104
Title: | Could serum pentraxin 3 levels and IgM deposition in skin biopsies predict subsequent renal involvement in children with Henoch–Schönlein purpura? | Authors: | Yüksel, Selçuk Çağlar, Murat Evrengül, Havva Becerir, Tülay Tepeli, Emre Ergin, Ahmet Avcı Çiçek, Esin |
Keywords: | Early predictor Henoch–Schönlein purpura Nephritis Pentraxin 3 Vasculitis biological marker C reactive protein immunoglobulin M pentraxin 3 serum amyloid P adolescent biopsy blood case control study child complication disease course enzyme linked immunosorbent assay evaluation study female fluorescent antibody technique human immunology male nephritis predictive value preschool child prognosis prospective study Purpura, Schoenlein-Henoch skin time upregulation Adolescent Biomarkers Biopsy C-Reactive Protein Case-Control Studies Child Child, Preschool Disease Progression Enzyme-Linked Immunosorbent Assay Female Fluorescent Antibody Technique Humans Immunoglobulin M Male Predictive Value of Tests Prognosis Prospective Studies Serum Amyloid P-Component Skin Time Factors Up-Regulation |
Publisher: | Springer Verlag | Abstract: | Background: The aim of this study was to evaluate the potential of serum pentraxin 3 (PTX3) values as an early predictor of subsequent renal involvement in patients with Henoch–Schönlein purpura (HSP) with no abnormalities on urinary examination and in renal function tests at disease onset. Methods: This was a prospective cohort study which included 60 pediatric patients with HSP (age range 3–15 years) who were diagnosed between February 2011 and October 2012 and 60 age- and sex-matched healthy controls. The patients were followed up for at least 18 months. Clinical findings were recorded for all patients at first examination, and blood samples for routine laboratory parameters and PTX3 value as well as skin biopsy specimens were obtained from each subject. Results: Of the 60 patients with HSP, 29 (48.3 %) developed subsequent renal involvement, of whom four underwent kidney biopsy. The mean serum PTX3 level of patients with subsequent renal involvement was significantly higher than those of patients without renal involvement and of the controls (2.20 ± 1.30 vs. 1.36 ± 0.85 and 1.03 ± 0.7 ng/ml, respectively; p = 0.004). Immunofluorescence evaluation of skin biopsy revealed that in addition to immunoglobulin A (IgA) deposition, the IgM deposition was significantly associated with subsequent renal involvement (p = 0.008). Conclusions: A high PTX3 level and IgM staining in skin biopsies from HSP patients may be harbingers of subsequent renal involvement. © 2014, IPNA. | URI: | https://hdl.handle.net/11499/10104 https://doi.org/10.1007/s00467-014-3026-x |
ISSN: | 0931-041X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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