Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10107
Title: The value of uterine artery Doppler and NT-proBNP levels in the second trimester to predict preeclampsia
Authors: Uyar, İbrahim
Kurt, Sefa
Demirtaş, Ömer
Gürbüz, Tutku
Aldemir, Onur Süleyman
Keser, Buket
Taşyurt, Abdullah
Keywords: NT-proBNP
Perinatal outcome
Uterine artery doppler
brain natriuretic peptide
peptide fragment
pro-brain natriuretic peptide (1-76)
adult
blood
cesarean section
cohort analysis
Doppler flowmetry
echography
female
fetus echography
human
Pre-Eclampsia
pregnancy
pregnancy outcome
procedures
prospective study
second trimester pregnancy
uterine artery
young adult
Adult
Cesarean Section
Cohort Studies
Female
Humans
Natriuretic Peptide, Brain
Peptide Fragments
Pregnancy
Pregnancy Outcome
Pregnancy Trimester, Second
Prospective Studies
Ultrasonography, Doppler
Ultrasonography, Prenatal
Uterine Artery
Young Adult
Publisher: Springer Verlag
Abstract: Objective: To determine the maternal serum N-Terminal proBNP levels in predicting development of preeclampsia. Method: Sixty-eight patients were included in the study. The study group consisted of patients with the finding of diastolic notch with abnormal pulsatility index (PI) between 21–24 weeks gestation and the control group consisted of patients without diastolic notch and normal PI. The study included high-risk patients who did not have a history of hypertensive disorder before pregnancy, heart failure, recurrent pregnancy loss, autoimmune disorder or diabetes. The groups were compared in terms of NT-ProBNP levels, development of preeclampsia, obstetric and neonatal problems. Results: There was no significant difference between groups in terms of age, gravidity, parity, uric acid levels, and NT-proBNP levels. There was significant difference between the groups in terms of week of birth, rate of cesarean section and fetal weight. Furthermore, there were significant differences between the two groups when compared in terms of obstetric and neonatal problems (p < 0.05). Obstetric and neonatal problems were more common in the notch with abnormal (PI) group. The NT-pro BNP levels were found to be comparable among groups. Preeclampsia was the most common obstetric problem (11.7 %). We were unable to document significant difference in patients who developed preeclampsia. Conclusion: Bilateral notch together with abnormal PI measurements in the uterine artery Doppler screening during the second trimester was associated with poor perinatal outcomes. Such an association was not significant in the NT-proBNP measurements. Larger trials focused on late-onset preeclampsia are needed to draw definitive conclusions. © 2014, Springer-Verlag Berlin Heidelberg.
URI: https://hdl.handle.net/11499/10107
https://doi.org/10.1007/s00404-014-3563-3
ISSN: 0932-0067
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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