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https://hdl.handle.net/11499/10107
Title: | The value of uterine artery Doppler and NT-proBNP levels in the second trimester to predict preeclampsia | Authors: | Uyar, İbrahim Kurt, Sefa Demirtaş, Ömer Gürbüz, Tutku Aldemir, Onur Süleyman Keser, Buket Taşyurt, Abdullah |
Keywords: | NT-proBNP Perinatal outcome Uterine artery doppler brain natriuretic peptide peptide fragment pro-brain natriuretic peptide (1-76) adult blood cesarean section cohort analysis Doppler flowmetry echography female fetus echography human Pre-Eclampsia pregnancy pregnancy outcome procedures prospective study second trimester pregnancy uterine artery young adult Adult Cesarean Section Cohort Studies Female Humans Natriuretic Peptide, Brain Peptide Fragments Pregnancy Pregnancy Outcome Pregnancy Trimester, Second Prospective Studies Ultrasonography, Doppler Ultrasonography, Prenatal Uterine Artery Young Adult |
Publisher: | Springer Verlag | Abstract: | Objective: To determine the maternal serum N-Terminal proBNP levels in predicting development of preeclampsia. Method: Sixty-eight patients were included in the study. The study group consisted of patients with the finding of diastolic notch with abnormal pulsatility index (PI) between 21–24 weeks gestation and the control group consisted of patients without diastolic notch and normal PI. The study included high-risk patients who did not have a history of hypertensive disorder before pregnancy, heart failure, recurrent pregnancy loss, autoimmune disorder or diabetes. The groups were compared in terms of NT-ProBNP levels, development of preeclampsia, obstetric and neonatal problems. Results: There was no significant difference between groups in terms of age, gravidity, parity, uric acid levels, and NT-proBNP levels. There was significant difference between the groups in terms of week of birth, rate of cesarean section and fetal weight. Furthermore, there were significant differences between the two groups when compared in terms of obstetric and neonatal problems (p < 0.05). Obstetric and neonatal problems were more common in the notch with abnormal (PI) group. The NT-pro BNP levels were found to be comparable among groups. Preeclampsia was the most common obstetric problem (11.7 %). We were unable to document significant difference in patients who developed preeclampsia. Conclusion: Bilateral notch together with abnormal PI measurements in the uterine artery Doppler screening during the second trimester was associated with poor perinatal outcomes. Such an association was not significant in the NT-proBNP measurements. Larger trials focused on late-onset preeclampsia are needed to draw definitive conclusions. © 2014, Springer-Verlag Berlin Heidelberg. | URI: | https://hdl.handle.net/11499/10107 https://doi.org/10.1007/s00404-014-3563-3 |
ISSN: | 0932-0067 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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