Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10110
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dc.contributor.authorÇetin, Gökhan Ozan-
dc.contributor.authorToylu, Aslı-
dc.contributor.authorAtabey, Neşe-
dc.contributor.authorSercan, Zeynep-
dc.contributor.authorSakızlı, Meral-
dc.date.accessioned2019-08-16T13:11:38Z
dc.date.available2019-08-16T13:11:38Z
dc.date.issued2015-
dc.identifier.issn1945-0265-
dc.identifier.urihttps://hdl.handle.net/11499/10110-
dc.identifier.urihttps://doi.org/10.1089/gtmb.2015.0014-
dc.description.abstractAims: The Wnt planar cell polarity (PCP) pathway is one of the Wnt pathways which plays a critical role in cell proliferation and fate. The VANGL1 protein is one of Wnt-PCP pathway components. It is known that Wnt-PCP pathway has major roles in cell motility but its role in hepatocellular carcinoma (HCC) progression through invasion and metastasis needs to be clarified. Methods: We silenced VANGL1 gene expression in the HepG2 HCC cell line by stable transfection with a vector containing siRNA template for VANGL1 and investigated the change in cell invasion and motility. Results: Transfected cells with the siRNA template showed significantly suppressed invasive capacity when compared to controls although cellular motility was only slightly affected. Conclusion: Our study showed a basal role for VANGL1 with respect to the invasive capacity of HCC cells. This suggests that the Wnt-PCP pathway may play a role in progression of HCC through cellular invasion but further studies are needed to clarify its role in cell motility. © 2015, Mary Ann Liebert, Inc.en_US
dc.language.isoenen_US
dc.publisherMary Ann Liebert Inc.en_US
dc.relation.ispartofGenetic Testing and Molecular Biomarkersen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmessenger RNAen_US
dc.subjectprotein VANGL1en_US
dc.subjectsmall interfering RNAen_US
dc.subjectunclassified drugen_US
dc.subjectWnt proteinen_US
dc.subjectcarrier proteinen_US
dc.subjectmembrane proteinen_US
dc.subjectVANGL1 protein, humanen_US
dc.subjectArticleen_US
dc.subjectcancer growthen_US
dc.subjectcell fateen_US
dc.subjectcell invasionen_US
dc.subjectcell motilityen_US
dc.subjectcell polarityen_US
dc.subjectcell proliferationen_US
dc.subjectcontrolled studyen_US
dc.subjectdown regulationen_US
dc.subjectgeneen_US
dc.subjectgene expressionen_US
dc.subjectgene silencingen_US
dc.subjectgenetic transfectionen_US
dc.subjectHepG2 cell lineen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectliver cell carcinomaen_US
dc.subjectVANGL1 geneen_US
dc.subjectantagonists and inhibitorsen_US
dc.subjectbiosynthesisen_US
dc.subjectcell motionen_US
dc.subjectgeneticsen_US
dc.subjectHep-G2 cell lineen_US
dc.subjectliver tumoren_US
dc.subjectmetabolismen_US
dc.subjectpathologyen_US
dc.subjectphysiologyen_US
dc.subjectsignal transductionen_US
dc.subjecttumor cell lineen_US
dc.subjecttumor invasionen_US
dc.subjectWnt signaling pathwayen_US
dc.subjectCarcinoma, Hepatocellularen_US
dc.subjectCarrier Proteinsen_US
dc.subjectCell Line, Tumoren_US
dc.subjectCell Movementen_US
dc.subjectDown-Regulationen_US
dc.subjectGene Expressionen_US
dc.subjectHep G2 Cellsen_US
dc.subjectHumansen_US
dc.subjectLiver Neoplasmsen_US
dc.subjectMembrane Proteinsen_US
dc.subjectNeoplasm Invasivenessen_US
dc.subjectRNA, Small Interferingen_US
dc.subjectSignal Transductionen_US
dc.subjectTransfectionen_US
dc.subjectWnt Signaling Pathwayen_US
dc.titleDownregulation of VANGL1 inhibits cellular invasion rather than cell motility in hepatocellular carcinoma cells without stimulationen_US
dc.typeArticleen_US
dc.identifier.volume19en_US
dc.identifier.issue6en_US
dc.identifier.startpage283
dc.identifier.startpage283en_US
dc.identifier.endpage287en_US
dc.identifier.doi10.1089/gtmb.2015.0014-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid25874746en_US
dc.identifier.scopus2-s2.0-84930890534en_US
dc.identifier.wosWOS:000363885000002en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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