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https://hdl.handle.net/11499/10112
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DC Field | Value | Language |
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dc.contributor.author | Seyit, Murat | - |
dc.contributor.author | Erdur, Bülent | - |
dc.contributor.author | Kortunay, Selim | - |
dc.contributor.author | Yuksel, Aykut | - |
dc.contributor.author | Yılmaz, Atakan | - |
dc.contributor.author | Özen, Mert | - |
dc.contributor.author | Uyanık, Aykut | - |
dc.date.accessioned | 2019-08-16T13:11:40Z | |
dc.date.available | 2019-08-16T13:11:40Z | |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2074-1804 | - |
dc.identifier.uri | https://hdl.handle.net/11499/10112 | - |
dc.identifier.uri | https://doi.org/10.5812/ircmj.17(5)2015.18780 | - |
dc.description.abstract | Background: The treatment of cocaine toxicity is an important subject for emergency physicians. We investigated the effects of dexmedetomidine, moxonidine and alpha-methyldopa on acute cocaine toxicity in mice. Objectives: The aim of this study was to evaluate the effects of dexmedetomidine, moxonidine and alpha-methyldopa in a mouse model of acute cocaine toxicity. Materials and Methods: We performed an experiment consisting of four groups (n = 25 each). The first group received normal saline solution, the second group received 40 µg/kg of dexmedetomidine, the third group received 0.1 mg/kg of moxonidine and the fourth group received 200 mg/kg of alpha-methyldopa, all of which were intraperitoneally administered 10 minutes before cocaine hydrochloride (105 mg/kg). All animals were observed for seizures (popcorn jumping, tonic-clonic activity, or a loss of the righting reflex) and lethality over the 30 minutes following cocaine treatment. Results: The ratio of animals with convulsions was lower in all treated groups when compared to the control (P < 0.001). Furthermore, 68% (n = 17) of animals in the dexmedetomidine group, 84% (n = 21) of the alpha-methyldopa group, 92% (n = 23) of the moxonidine group and 100% (n = 25) of the control group showed evidence of seizure activity (P = 0.009). Cocaine-induced lethality was observed in 12% (n = 3) of the dexmedetomidine group, 48% (n = 12) of the alpha-methyldopa group, 52% (n = 13) of the moxonidine group, and 72% (n = 18) of the control group (P < 0.001). All treatments prolonged the time to seizure, which was longest in the dexmedetomidine group (P > 0.05). In addition, the time to lethality was also longer in the same group (P < 0.001). Conclusions: The present study provides the first experimental evidence in support of dexmedetomidine treatment for cocaine-induced seizures. Premedication with dexmedetomidine reduces seizure activity in a mouse model of acute cocaine toxicity. In addition, while dexmedetomidine may be effective, moxonidine and alpha-methyldopa did not effectively prevent cocaine-induced lethality. © 2015, Iranian Red Crescent Medical Journal. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Kowsar Medical Publishing Company | en_US |
dc.relation.ispartof | Iranian Red Crescent Medical Journal | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Alpha-Methyldopa | en_US |
dc.subject | Cocaine | en_US |
dc.subject | Dexmedetomidine | en_US |
dc.subject | Intoxication | en_US |
dc.subject | Moxonidine | en_US |
dc.subject | cocaine | en_US |
dc.subject | dexmedetomidine | en_US |
dc.subject | methyldopa | en_US |
dc.subject | moxonidine | en_US |
dc.subject | placebo | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | Article | en_US |
dc.subject | cocaine dependence | en_US |
dc.subject | cocaine toxicity | en_US |
dc.subject | comparative effectiveness | en_US |
dc.subject | controlled study | en_US |
dc.subject | convulsion | en_US |
dc.subject | intoxication | en_US |
dc.subject | lethality | en_US |
dc.subject | mouse | en_US |
dc.subject | nonhuman | en_US |
dc.subject | outcome assessment | en_US |
dc.title | A comparison of dexmedetomidine, moxonidine and alpha-methyldopa effects on acute, lethal cocaine toxicity | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.doi | 10.5812/ircmj.17(5)2015.18780 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 26290748 | en_US |
dc.identifier.scopus | 2-s2.0-85008339375 | en_US |
dc.identifier.wos | WOS:000360809500001 | en_US |
dc.identifier.scopusquality | Q3 | - |
dc.owner | Pamukkale University | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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Murat Seyit.pdf | 403.15 kB | Adobe PDF | View/Open |
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