Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10112
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dc.contributor.authorSeyit, Murat-
dc.contributor.authorErdur, Bülent-
dc.contributor.authorKortunay, Selim-
dc.contributor.authorYuksel, Aykut-
dc.contributor.authorYılmaz, Atakan-
dc.contributor.authorÖzen, Mert-
dc.contributor.authorUyanık, Aykut-
dc.date.accessioned2019-08-16T13:11:40Z
dc.date.available2019-08-16T13:11:40Z
dc.date.issued2015-
dc.identifier.issn2074-1804-
dc.identifier.urihttps://hdl.handle.net/11499/10112-
dc.identifier.urihttps://doi.org/10.5812/ircmj.17(5)2015.18780-
dc.description.abstractBackground: The treatment of cocaine toxicity is an important subject for emergency physicians. We investigated the effects of dexmedetomidine, moxonidine and alpha-methyldopa on acute cocaine toxicity in mice. Objectives: The aim of this study was to evaluate the effects of dexmedetomidine, moxonidine and alpha-methyldopa in a mouse model of acute cocaine toxicity. Materials and Methods: We performed an experiment consisting of four groups (n = 25 each). The first group received normal saline solution, the second group received 40 µg/kg of dexmedetomidine, the third group received 0.1 mg/kg of moxonidine and the fourth group received 200 mg/kg of alpha-methyldopa, all of which were intraperitoneally administered 10 minutes before cocaine hydrochloride (105 mg/kg). All animals were observed for seizures (popcorn jumping, tonic-clonic activity, or a loss of the righting reflex) and lethality over the 30 minutes following cocaine treatment. Results: The ratio of animals with convulsions was lower in all treated groups when compared to the control (P < 0.001). Furthermore, 68% (n = 17) of animals in the dexmedetomidine group, 84% (n = 21) of the alpha-methyldopa group, 92% (n = 23) of the moxonidine group and 100% (n = 25) of the control group showed evidence of seizure activity (P = 0.009). Cocaine-induced lethality was observed in 12% (n = 3) of the dexmedetomidine group, 48% (n = 12) of the alpha-methyldopa group, 52% (n = 13) of the moxonidine group, and 72% (n = 18) of the control group (P < 0.001). All treatments prolonged the time to seizure, which was longest in the dexmedetomidine group (P > 0.05). In addition, the time to lethality was also longer in the same group (P < 0.001). Conclusions: The present study provides the first experimental evidence in support of dexmedetomidine treatment for cocaine-induced seizures. Premedication with dexmedetomidine reduces seizure activity in a mouse model of acute cocaine toxicity. In addition, while dexmedetomidine may be effective, moxonidine and alpha-methyldopa did not effectively prevent cocaine-induced lethality. © 2015, Iranian Red Crescent Medical Journal.en_US
dc.language.isoenen_US
dc.publisherKowsar Medical Publishing Companyen_US
dc.relation.ispartofIranian Red Crescent Medical Journalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlpha-Methyldopaen_US
dc.subjectCocaineen_US
dc.subjectDexmedetomidineen_US
dc.subjectIntoxicationen_US
dc.subjectMoxonidineen_US
dc.subjectcocaineen_US
dc.subjectdexmedetomidineen_US
dc.subjectmethyldopaen_US
dc.subjectmoxonidineen_US
dc.subjectplaceboen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectArticleen_US
dc.subjectcocaine dependenceen_US
dc.subjectcocaine toxicityen_US
dc.subjectcomparative effectivenessen_US
dc.subjectcontrolled studyen_US
dc.subjectconvulsionen_US
dc.subjectintoxicationen_US
dc.subjectlethalityen_US
dc.subjectmouseen_US
dc.subjectnonhumanen_US
dc.subjectoutcome assessmenten_US
dc.titleA comparison of dexmedetomidine, moxonidine and alpha-methyldopa effects on acute, lethal cocaine toxicityen_US
dc.typeArticleen_US
dc.identifier.volume17en_US
dc.identifier.issue6en_US
dc.identifier.doi10.5812/ircmj.17(5)2015.18780-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid26290748en_US
dc.identifier.scopus2-s2.0-85008339375en_US
dc.identifier.wosWOS:000360809500001en_US
dc.identifier.scopusqualityQ3-
dc.ownerPamukkale University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
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Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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