Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10140
Title: Angiotensinogen gene M235T and angiotensin ii-type 1 receptor gene A/C1166 polymorphisms in chronic obtructive pulmonary disease
Authors: Ayada, Ceylan
Toru, Umran
Genç, Osman
Şahin, Server
Turgut, Sebahat
Turgut, Günfer
Keywords: A/C1166 polymorphism
Angiotensin-II type 1 receptor
Angiotensinogen
Chronic obstructive pulmonary disease
M235T polymorphism
angiotensin 1 receptor
angiotensinogen
allele
angiotensin II type 1 receptor gene A
angiotensinogen gene
Article
chronic obstructive lung disease
controlled study
female
gene
gene frequency
genetic association
genotype
homozygosity
human
major clinical study
male
polymerase chain reaction
single nucleotide polymorphism
Publisher: E-Century Publishing Corporation
Abstract: Chronic obstructive pulmonary disease (COPD) occurs irreversibly and is characterized by progressive airflow obstruction. Renin angiotensin system (RAS) has many different key enzymes and receptors that have a role for different systemic processes. We aimed to determine genotype and allele frequencies of angiotensinogen (AGT) M235T and angiotensin II-type 1 receptor (AT1-R) A/C1166 polymorphisms in patients with COPD. This study was performed on 56 unrelated COPD patients and 29 healthy subjects. DNA samples for each individual were isolated from peripheral blood by phenol/chloroform method, analyzed by polymerase chain reaction and enzymatic digestion methodologies. The distribution for each of AGT genotypes were 23.2% for MM (13), 75.0% for MT (42) and 1.8% for TT (1) in the COPD group; 37.9% for MM (11), 34.5% for MT (10) and 27.6% for TT (8) in the control group. The distribution of AGT genotypes was found significantly different between groups (X2 = 18.604; df = 2; P = 0.000). The frequencies for each of the AT1-R genotypes were found as 53.6% for AA (30), 42.9% for AC (24), 3.6% for CC (2) in the COPD group; 55.2% for AA (16), 41.4% for AC (12) and 3.4% for CC (1) in the control group. The distribution of AT1-R genotypes did not change significantly between groups. Allele frequencies of interested genes were not significantly different between groups. We suggest that AGT polymorphism may play a role for the development of COPD. We believe these data can be served for large scale population genetics research, considering the frequency of AGT and AT1-R genes and alleles in COPD patients in the Turkish population. © 2015, Int J Clin Exp Med. All rights reserved.
URI: https://hdl.handle.net/11499/10140
ISSN: 1940-5901
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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