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https://hdl.handle.net/11499/10148
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Akcılar, Raziye | - |
dc.contributor.author | Turgut, Sebahat | - |
dc.contributor.author | Caner, Vildan | - |
dc.contributor.author | Akcilar, A. | - |
dc.contributor.author | Ayada, C. | - |
dc.contributor.author | Elmas, L. | - |
dc.contributor.author | Özcan, T.O. | - |
dc.date.accessioned | 2019-08-16T13:12:29Z | |
dc.date.available | 2019-08-16T13:12:29Z | |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1896-1126 | - |
dc.identifier.uri | https://hdl.handle.net/11499/10148 | - |
dc.identifier.uri | https://doi.org/10.1016/j.advms.2014.11.001 | - |
dc.description.abstract | Purpose: Apelin is an adipokine that plays a role in the regulation of many biological functions in mammals including the neuroendocrine, cardiovascular, immune systems, glucose homeostasis and obesity. It can act via autocrine, paracrine, endocrine, and exocrine signaling. We aimed to identify the role of apelin pathophysiology of diabetes. Material/methods: 37 male Wistar Albino rats aged 8-10 weeks were divided in four experimental groups as: control group (C) control + apelin group (C + A), diabetic group (D) diabetic + apelin group (D + A). Apelin and apelin receptor mRNA gene expressions in heart and aorta tissue were determined by real-time polymerase chain reaction. The plasma levels of insulin and plasma apelin were determined by ELISA. Results Plasma levels of insulin, glucose, blood pressure levels were significantly lower in D + A group. There was no statistically significant difference for level of apelin between diabetic groups. On the other hand, differences for apelin and APJ mRNA expression in heart and vascular tissue were found significant between groups. Conclusions: Apelin can be used as a therapeutic agent in the treatment of type II diabetes in the future. © 2014 Medical University of Bialystok. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Medical University of Bialystok | en_US |
dc.relation.ispartof | Advances in Medical Sciences | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Alloxan | en_US |
dc.subject | Apelin | en_US |
dc.subject | Apelin receptor (APJ) | en_US |
dc.subject | Blood pressure | en_US |
dc.subject | Glucose metabolism | en_US |
dc.subject | Type II diabetes | en_US |
dc.subject | angiotensin II | en_US |
dc.subject | angiotensinogen | en_US |
dc.subject | antidiabetic agent | en_US |
dc.subject | apelin | en_US |
dc.subject | apelin receptor | en_US |
dc.subject | endothelin 1 | en_US |
dc.subject | glucose | en_US |
dc.subject | insulin | en_US |
dc.subject | messenger RNA | en_US |
dc.subject | peptide derivative | en_US |
dc.subject | pyroglutamylated apelin 13 | en_US |
dc.subject | unclassified drug | en_US |
dc.subject | APLN protein, human | en_US |
dc.subject | APLNR protein, human | en_US |
dc.subject | G protein coupled receptor | en_US |
dc.subject | signal peptide | en_US |
dc.subject | angiotensin blood level | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | animal tissue | en_US |
dc.subject | antidiabetic activity | en_US |
dc.subject | Article | en_US |
dc.subject | blood pressure | en_US |
dc.subject | blood pressure measurement | en_US |
dc.subject | body weight | en_US |
dc.subject | controlled study | en_US |
dc.subject | enzyme linked immunosorbent assay | en_US |
dc.subject | gene expression | en_US |
dc.subject | glucose blood level | en_US |
dc.subject | heart | en_US |
dc.subject | heart weight | en_US |
dc.subject | insulin blood level | en_US |
dc.subject | male | en_US |
dc.subject | molecular pathology | en_US |
dc.subject | non insulin dependent diabetes mellitus | en_US |
dc.subject | nonhuman | en_US |
dc.subject | protein blood level | en_US |
dc.subject | rat | en_US |
dc.subject | real time polymerase chain reaction | en_US |
dc.subject | renin angiotensin aldosterone system | en_US |
dc.subject | vascular tissue | en_US |
dc.subject | Wistar rat | en_US |
dc.subject | animal | en_US |
dc.subject | blood | en_US |
dc.subject | Diabetes Mellitus, Type 2 | en_US |
dc.subject | drug effects | en_US |
dc.subject | genetics | en_US |
dc.subject | metabolism | en_US |
dc.subject | Animals | en_US |
dc.subject | Blood Pressure | en_US |
dc.subject | Hypoglycemic Agents | en_US |
dc.subject | Insulin | en_US |
dc.subject | Intercellular Signaling Peptides and Proteins | en_US |
dc.subject | Male | en_US |
dc.subject | Rats | en_US |
dc.subject | Rats, Wistar | en_US |
dc.subject | Receptors, G-Protein-Coupled | en_US |
dc.subject | RNA, Messenger | en_US |
dc.title | The effects of apelin treatment on a rat model of type 2 diabetes | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 60 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 94 | |
dc.identifier.startpage | 94 | en_US |
dc.identifier.endpage | 100 | en_US |
dc.identifier.doi | 10.1016/j.advms.2014.11.001 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 25625368 | en_US |
dc.identifier.scopus | 2-s2.0-84927748550 | en_US |
dc.identifier.wos | WOS:000358555200015 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale University | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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