Association between igf-1 and atrial fibrillation in cerebrovascular disease

Abstract

Objective: The neuroprotective effect of insulin like growth factor (IGF-1) and its positive efficacy at prognosis of patients with acute cerebrovascular diseases (CVD) have been defined recently. Therefore, in our study, we aimed to investigate the relationship between IGF-1 and the severity of CVD, subgroups of CVD, and risk factors of CVD. Material and Method: One hundred and five consecutive ischemic CVD patients were enrolled to the study. National Institute of Health Stroke (NIHS) Scale were performed to the patients at their 1st and 15th days of hospitalizations. Risk factors of patients were recorded. Patients were grouped according to CVD subgroups. The relationship between IGF-1 levels and the NIHS scale, subgroups of CVD, and risk factors of CVD were investigated. Results: There was a weak reverse correlation between IGF-1 level and NIHS scale. Amongs risk factors; atrial fibrillation (AF) group had the lowest level of IGF-1. Conclusion: Patients with AF had the lowest level of IGF- 1 when compared to the levels of IGF-1 of other risk factors. © Nobel İlaç AŞ.