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https://hdl.handle.net/11499/10224
Title: | Effect of 10-week supervised moderate-intensity intermittent vs. continuous aerobic exercise programs on vascular adhesion molecules in patients with heart failure | Authors: | Aksoy, Sibel Fındıkoğlu, Gülin Ardıç, Füsun Rota, Simin Dursunoglu, Dursun |
Keywords: | Cardiac rehabilitation NO sICAM-1 sVCAM-1 brain natriuretic peptide cell adhesion molecule intercellular adhesion molecule 1 nitric oxide peptide fragment pro-brain natriuretic peptide (1-76) vascular cell adhesion molecule 1 adult aged blood body composition comparative study controlled study female heart failure heart stroke volume human kinesiotherapy male middle aged pathophysiology physiology procedures prospective study quality of life randomized controlled trial vascular endothelium very elderly Adult Aged Aged, 80 and over Body Composition Cell Adhesion Molecules Endothelium, Vascular Exercise Therapy Female Heart Failure Humans Intercellular Adhesion Molecule-1 Male Middle Aged Natriuretic Peptide, Brain Nitric Oxide Peptide Fragments Prospective Studies Quality of Life Stroke Volume Vascular Cell Adhesion Molecule-1 |
Publisher: | Lippincott Williams and Wilkins | Abstract: | Objective: Abnormal expression of cellular adhesion molecules may be related to endothelial dysfunction, a key feature in chronic heart failure. This study compares the effects of 10-wk supervised moderate-intensity continuous aerobic exercise (CAE) and intermittent aerobic exercise (IAE) programs on markers of endothelial damage, disease severity, functional and metabolic status, and quality-of-life in chronic heart failure patients. Design: Fifty-seven patients between 41 and 81 yrs with New York Heart Association class IIYIII chronic heart failure and with a left ventricular ejection fraction of 35%-55% were randomized into three groups: nonexercising control, CAE, and IAE, which exercised three times a week for 10 wks. Endothelial damage was assessed by serum markers of vascular cell adhesion molecule-1, serum intercellular adhesion molecule-1, and nitric oxide; disease severity was measured by left ventricular ejection fraction and N-terminal probrain natriuretic peptide; metabolic status was evaluated by body composition analysis and lipid profile levels; functional status was evaluated by cardiorespiratory exercise stress test and 6-min walking distance; quality-of-life was assessed with Left Ventricular Dysfunction-36 and Short-Form 36 questionnaires at the baseline and at the end of the 10th week. Results: Significant decreases in serum vascular cell adhesion molecule-1 or serum intercellular adhesion molecule-1 in IAE and CAE groups after training were found, respectively. Resting systolic and diastolic blood pressure, peak systolic and diastolic blood pressure, 6-min walking distance, and the mental health and vitality components of Short-Form 36 improved in the CAE group, whereas left ventricular ejection fraction and 6-min walking distance improved in the IAE group compared with the control group. Conclusions: Both moderate-intensity CAE and IAE programs significantly reduced serum markers of adhesion molecules and prevented the change in VO<inf>2</inf> in patients with chronic heart failure. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. | URI: | https://hdl.handle.net/11499/10224 https://doi.org/10.1097/PHM.0000000000000306 |
ISSN: | 0894-9115 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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