Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10224
Title: Effect of 10-week supervised moderate-intensity intermittent vs. continuous aerobic exercise programs on vascular adhesion molecules in patients with heart failure
Authors: Aksoy, Sibel
Fındıkoğlu, Gülin
Ardıç, Füsun
Rota, Simin
Dursunoglu, Dursun
Keywords: Cardiac rehabilitation
NO
sICAM-1
sVCAM-1
brain natriuretic peptide
cell adhesion molecule
intercellular adhesion molecule 1
nitric oxide
peptide fragment
pro-brain natriuretic peptide (1-76)
vascular cell adhesion molecule 1
adult
aged
blood
body composition
comparative study
controlled study
female
heart failure
heart stroke volume
human
kinesiotherapy
male
middle aged
pathophysiology
physiology
procedures
prospective study
quality of life
randomized controlled trial
vascular endothelium
very elderly
Adult
Aged
Aged, 80 and over
Body Composition
Cell Adhesion Molecules
Endothelium, Vascular
Exercise Therapy
Female
Heart Failure
Humans
Intercellular Adhesion Molecule-1
Male
Middle Aged
Natriuretic Peptide, Brain
Nitric Oxide
Peptide Fragments
Prospective Studies
Quality of Life
Stroke Volume
Vascular Cell Adhesion Molecule-1
Publisher: Lippincott Williams and Wilkins
Abstract: Objective: Abnormal expression of cellular adhesion molecules may be related to endothelial dysfunction, a key feature in chronic heart failure. This study compares the effects of 10-wk supervised moderate-intensity continuous aerobic exercise (CAE) and intermittent aerobic exercise (IAE) programs on markers of endothelial damage, disease severity, functional and metabolic status, and quality-of-life in chronic heart failure patients. Design: Fifty-seven patients between 41 and 81 yrs with New York Heart Association class IIYIII chronic heart failure and with a left ventricular ejection fraction of 35%-55% were randomized into three groups: nonexercising control, CAE, and IAE, which exercised three times a week for 10 wks. Endothelial damage was assessed by serum markers of vascular cell adhesion molecule-1, serum intercellular adhesion molecule-1, and nitric oxide; disease severity was measured by left ventricular ejection fraction and N-terminal probrain natriuretic peptide; metabolic status was evaluated by body composition analysis and lipid profile levels; functional status was evaluated by cardiorespiratory exercise stress test and 6-min walking distance; quality-of-life was assessed with Left Ventricular Dysfunction-36 and Short-Form 36 questionnaires at the baseline and at the end of the 10th week. Results: Significant decreases in serum vascular cell adhesion molecule-1 or serum intercellular adhesion molecule-1 in IAE and CAE groups after training were found, respectively. Resting systolic and diastolic blood pressure, peak systolic and diastolic blood pressure, 6-min walking distance, and the mental health and vitality components of Short-Form 36 improved in the CAE group, whereas left ventricular ejection fraction and 6-min walking distance improved in the IAE group compared with the control group. Conclusions: Both moderate-intensity CAE and IAE programs significantly reduced serum markers of adhesion molecules and prevented the change in VO<inf>2</inf> in patients with chronic heart failure. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
URI: https://hdl.handle.net/11499/10224
https://doi.org/10.1097/PHM.0000000000000306
ISSN: 0894-9115
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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