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https://hdl.handle.net/11499/10256
Title: | Relationship of apelin, procalcitonin, and fetuin-A concentrations with carotid intima-media thickness in acromegaly | Authors: | Topsakal, Senay Akin, Fulya Turgut, Sebahat Yaylalı, Güzin Fidan Herek, Duygu Ayada, Ceylan |
Keywords: | Acromegaly apelin carotid intima media thickness fetuin-A procalcitonin cholesterol creatinine fetuin A glucose growth hormone high density lipoprotein cholesterol insulin low density lipoprotein cholesterol somatomedin binding protein 3 somatomedin C triacylglycerol APLN protein, human calcitonin protein precursor signal peptide acromegaly adult age arterial wall thickness Article body height body mass body weight cholesterol blood level clinical article concentration (parameters) controlled study creatinine blood level diastolic blood pressure female glucose blood level growth hormone blood level human insulin blood level male priority journal systolic blood pressure triacylglycerol blood level blood case control study comparative study middle aged Adult alpha-2-HS-Glycoprotein Calcitonin Carotid Intima-Media Thickness Case-Control Studies Female Humans Intercellular Signaling Peptides and Proteins Male Middle Aged Protein Precursors |
Publisher: | SAGE Publications Ltd | Abstract: | Background Acromegaly is characterized by excess growth hormone and insulin-like growth factor-1 concentrations. There is conflicting evidence as to whether acromegaly is associated with an increased risk of atherosclerosis. Apelin is an adipose tissue-derived peptide that may be associated with hyperinsulinemia. Fetuin-A is a hepatocyte produced plasma glycoprotein that has an important role as a calcification inhibitor. The aim of this study was to examine apelin, fetuin-A, and procalcitonin concentrations and to assess their relationship with carotid intima medial thickness (cIMT) in subjects with acromegaly.MethodsApelin, fetuin-A, and procalcitonin serum concentrations were measured in 37 (20 inactive and 17 active) subjects with acromegaly and 30 control subjects, along with carotid intima medial thickness. Results The concentrations of apelin, fetuin-A, and procalcitonin were increased in subjects with acromegaly. There were significant correlations between apelin, fetuin-A, and procalcitonin in subjects with acromegaly. Carotid intima medial thickness values were similar between control subjects and subjects with acromegaly. Conclusions Carotid intima medial thickness was not increased in subjects with acromegaly. It is possible that the increased apelin and fetuin-A concentrations observed play a protective role against the development of atherosclerosis in subjects with acromegaly. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav. | URI: | https://hdl.handle.net/11499/10256 https://doi.org/10.1177/0004563214562431 |
ISSN: | 0004-5632 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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