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https://hdl.handle.net/11499/10311
Title: | Ketamine may be related to minor troponin elevations in children undergoing minor procedures in the ED | Authors: | Serinken, Mustafa Eken, C. |
Keywords: | ketamine troponin anesthetic agent troponin T Article child childhood injury clinical article diastolic blood pressure electrocardiogram emergency ward female follow up heart muscle injury human male minor surgery observational study outcome assessment priority journal pulse rate QT dispersion QT interval QTc interval sedation systolic blood pressure blood conscious sedation electrocardiography emergency health service Facial Injuries Hand Injuries heart muscle ischemia infant preschool child Anesthetics, Dissociative Child, Preschool Conscious Sedation Electrocardiography Emergency Service, Hospital Humans Infant Ketamine Myocardial Ischemia Troponin T |
Publisher: | W.B. Saunders | Abstract: | Objective Ketamine is a dissociative anesthetic agent that has an increased frequency of usage in the last years particularly in emergency departments. In the present study, we aimed to determine whether ketamine is related to myocardial injury in children undergoing minor procedures. Method Children younger than 18 years undergoing procedural sedation secondary to minor trauma composed the study population. Patients were administered ketamine with a dose of 1.5 mg/kg via intravenous route. QT interval was measured by Bazett's formula, and QT dispersion was determined by taking the average of 3 different QT intervals. High-sensitive troponin levels were measured before and 3 hours after the ketamine administration. Results A total of 30 patients were included into the study. Study subjects had a median age of 2 years (interquartile range, 1-4 years). There were 2 patients among the study patients who had troponin elevations 3 hours after the ketamine administrations. High-sensitive troponin levels of these 2 at the time of preketamine, 3, 5, and 24 hours after the ketamine administration were as follows: 5, 29, 15, and 5 ng/L and 3, 44, 41, and 4 ng/L, respectively. There was no difference before and after the ketamine administration for the corrected QT intervals and QT dispersions. Conclusion Ketamine may be related to minor troponin elevations in children undergoing procedural sedation without a permanent cardiac dysfunction. © 2015 Elsevier Inc. | URI: | https://hdl.handle.net/11499/10311 https://doi.org/10.1016/j.ajem.2015.03.061 |
ISSN: | 0735-6757 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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