Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/10317
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Saygin, M. | - |
dc.contributor.author | Çalişkan, Sadettin | - |
dc.contributor.author | Ozguner, M.F. | - |
dc.contributor.author | Gumral, N. | - |
dc.contributor.author | Comlekci, S. | - |
dc.contributor.author | Karahan, N. | - |
dc.date.accessioned | 2019-08-16T13:15:51Z | |
dc.date.available | 2019-08-16T13:15:51Z | |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0043-3144 | - |
dc.identifier.uri | https://hdl.handle.net/11499/10317 | - |
dc.identifier.uri | https://doi.org/10.7727/wimj.2014.205 | - |
dc.description.abstract | Objective: It has been suggested that electromagnetic radiation (EMR) by wireless devices (2.45 GHz) induces testicular apoptosis. We investigated if supplemental selenium (Se) and L-carnitine may reduce this adverse effect. Material: Twelve-week old maleWistar albino rats were used in this study. Twenty-four rats were equally divided into four groups which were named as: sham group, EMR-only, EMR+L-carnitine (1.5 mg L-carnitine/ kg/day) and EMR+Se (1.5 mg Se/kg/ every other day). Results: The level of Bcl-2, Bax, caspase-3 and -8 were compared and a significant difference was found between the sham and EMR-only groups (p < 0.05), and Bcl-2, Bax, caspase-3 and -8 expressions increased in the EMR-only group. The level of Bcl-2, Bax, tumour necrosis factor-alpha (TNF-?), caspase- 3 and -8 were compared and a significant difference was found between the sham and EMR+L-carnitine groups (p < 0.05) and Bcl-2, Bax, TNF-?, caspase-3 and -8 expressions increased in the EMR+L-carnitine group. The level of Bcl-2, Bax, TNF-?, caspase-3 and -8 were compared and a significant difference was found between the sham and EMR+Se groups (p < 0.05) and Bcl-2, Bax, TNF-?, caspase-3 and -8 expressions increased in the EMR+Se group. When the expression of caspase-8 was compared, a significant difference was found between the EMR-only and EMR+Se groups (p < 0.05). Caspase-8 expression decreased in EMR+Se group compared with EMR-only group. Conclusion: Electromagnetic radiation exposure resulted in testicular apoptosis in rats, mainly by the intrinsic pathways by down-regulated expression of caspase-8. Reduction in the activation of the intrinsic pathway of apoptosis was found higher with selenium administration compared with L-carnitine administration. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of the West Indies | en_US |
dc.relation.ispartof | West Indian Medical Journal | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | L-carnitine | en_US |
dc.subject | Selenium | en_US |
dc.subject | Spermatogenesis | en_US |
dc.subject | Testes | en_US |
dc.subject | Wi-Fi | en_US |
dc.subject | carnitine | en_US |
dc.subject | caspase 3 | en_US |
dc.subject | caspase 8 | en_US |
dc.subject | protein Bax | en_US |
dc.subject | protein bcl 2 | en_US |
dc.subject | selenium | en_US |
dc.subject | tumor necrosis factor | en_US |
dc.subject | animal cell | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal tissue | en_US |
dc.subject | apoptosis | en_US |
dc.subject | Article | en_US |
dc.subject | Bax gene | en_US |
dc.subject | Bcl 2 gene | en_US |
dc.subject | caspase 3 gene | en_US |
dc.subject | caspase 8 gene | en_US |
dc.subject | controlled study | en_US |
dc.subject | down regulation | en_US |
dc.subject | drug effect | en_US |
dc.subject | electromagnetic radiation | en_US |
dc.subject | experimental study | en_US |
dc.subject | gene control | en_US |
dc.subject | male | en_US |
dc.subject | microwave radiation | en_US |
dc.subject | nonhuman | en_US |
dc.subject | protein expression | en_US |
dc.subject | rat | en_US |
dc.subject | sham procedure | en_US |
dc.subject | testis cell | en_US |
dc.subject | testis tissue | en_US |
dc.subject | TNF alpha gene | en_US |
dc.subject | treatment response | en_US |
dc.subject | wireless communication | en_US |
dc.title | Impact of L-carnitine and selenium treatment on testicular apoptosis in rats exposed to 2.45 GHz microwave energy | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 64 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 55 | |
dc.identifier.startpage | 55 | en_US |
dc.identifier.endpage | 61 | en_US |
dc.identifier.doi | 10.7727/wimj.2014.205 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 26360675 | en_US |
dc.identifier.scopus | 2-s2.0-85007156903 | en_US |
dc.identifier.wos | WOS:000365569600001 | en_US |
dc.identifier.scopusquality | Q3 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
sadettin çalışkan.pdf | 661.48 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
10
checked on Jun 29, 2024
WEB OF SCIENCETM
Citations
8
checked on Jul 18, 2024
Page view(s)
18
checked on May 27, 2024
Download(s)
4
checked on May 27, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.