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https://hdl.handle.net/11499/10333
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Balcı, Yasemin Işık | - |
dc.contributor.author | Akpınar, Funda Özgürler | - |
dc.contributor.author | Polat, Aziz | - |
dc.contributor.author | Kenar, Fethullah | - |
dc.contributor.author | Tesi, B. | - |
dc.contributor.author | Greenwood, T. | - |
dc.contributor.author | Yalçın, Nagihan | - |
dc.date.accessioned | 2019-08-16T13:16:08Z | - |
dc.date.available | 2019-08-16T13:16:08Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1300-7777 | - |
dc.identifier.uri | https://hdl.handle.net/11499/10333 | - |
dc.identifier.uri | https://doi.org/10.4274/tjh.2014.0416 | - |
dc.description.abstract | Hemophagocytic lymphohistiocytosis (HLH) represents a severe hyperinflammatory condition with cardinal symptoms of prolonged fever, cytopenias, hepatosplenomegaly, and hemophagocytosis by activated, morphologically benign macrophages with impaired function of natural killer cells and cytotoxic T lymphocytes. A 2-month-old girl, who was admitted with fever, was diagnosed with HLH and her genetic examination revealed a newly defined mutation in the UNC13D (c.175G>C; p.Ala59Pro) gene. She was treated with dexamethasone, etoposide, and intrathecal methotrexate. During the second week of treatment, after three doses of etoposide, it was noticed that there was a necrotic plaque lesion on the soft palate. Pathologic examination of debrided material in PAS and Grocott staining revealed lots of septated hyphae, which was consistent with aspergillosis infection. Etoposide was stopped and amphotericin B treatment was given for six weeks. HLH 2004 protocol was completed to eight weeks with cyclosporine A orally. There was no patient with invasive aspergillosis infection as severe as causing palate and nasal septum perforation during HLH therapy. In immuncompromised patients, fungal infections may cause nasal septum perforation and treatment could be achieved by antifungal therapy and debridement of necrotic tissue. © 2015 Turkish Society of Hematology. All rights reserved. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Turkish Society of Hematology | en_US |
dc.relation.ispartof | Turkish Journal of Hematology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Hemophagocytic lymphohistiocytosis | en_US |
dc.subject | Invasive aspergillosis infection | en_US |
dc.subject | P.Ala59Pro) | en_US |
dc.subject | UNC13D (c.175G>C | en_US |
dc.subject | alanine aminotransferase | en_US |
dc.subject | amphotericin B | en_US |
dc.subject | aspartate aminotransferase | en_US |
dc.subject | cotrimoxazole | en_US |
dc.subject | cyclosporin A | en_US |
dc.subject | dexamethasone | en_US |
dc.subject | etoposide | en_US |
dc.subject | fluconazole | en_US |
dc.subject | cyclosporin | en_US |
dc.subject | membrane protein | en_US |
dc.subject | methotrexate | en_US |
dc.subject | UNC13D protein, human | en_US |
dc.subject | Article | en_US |
dc.subject | aspergillosis | en_US |
dc.subject | body temperature | en_US |
dc.subject | bone marrow biopsy | en_US |
dc.subject | case report | en_US |
dc.subject | erythrophagocytosis | en_US |
dc.subject | female | en_US |
dc.subject | fever | en_US |
dc.subject | gene | en_US |
dc.subject | gene mutation | en_US |
dc.subject | genetic analysis | en_US |
dc.subject | hemophagocytic syndrome | en_US |
dc.subject | hepatomegaly | en_US |
dc.subject | hepatosplenomegaly | en_US |
dc.subject | histiocyte | en_US |
dc.subject | human | en_US |
dc.subject | human tissue | en_US |
dc.subject | infant | en_US |
dc.subject | mutational analysis | en_US |
dc.subject | nose malformation | en_US |
dc.subject | rash | en_US |
dc.subject | soft palate | en_US |
dc.subject | splenomegaly | en_US |
dc.subject | tissue necrosis | en_US |
dc.subject | UNC13D gene | en_US |
dc.subject | amino acid substitution | en_US |
dc.subject | bone marrow transplantation | en_US |
dc.subject | combination drug therapy | en_US |
dc.subject | debridement | en_US |
dc.subject | genetics | en_US |
dc.subject | immunocompromised patient | en_US |
dc.subject | Lymphohistiocytosis, Hemophagocytic | en_US |
dc.subject | microbiology | en_US |
dc.subject | missense mutation | en_US |
dc.subject | multimodality cancer therapy | en_US |
dc.subject | Nasal Septal Perforation | en_US |
dc.subject | Opportunistic Infections | en_US |
dc.subject | point mutation | en_US |
dc.subject | stomatitis | en_US |
dc.subject | Amino Acid Substitution | en_US |
dc.subject | Amphotericin B | en_US |
dc.subject | Aspergillosis | en_US |
dc.subject | Bone Marrow Transplantation | en_US |
dc.subject | Combined Modality Therapy | en_US |
dc.subject | Cyclosporine | en_US |
dc.subject | Debridement | en_US |
dc.subject | Dexamethasone | en_US |
dc.subject | Drug Therapy, Combination | en_US |
dc.subject | Etoposide | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Immunocompromised Host | en_US |
dc.subject | Infant | en_US |
dc.subject | Membrane Proteins | en_US |
dc.subject | Methotrexate | en_US |
dc.subject | Mutation, Missense | en_US |
dc.subject | Palate, Soft | en_US |
dc.subject | Point Mutation | en_US |
dc.subject | Stomatitis | en_US |
dc.title | A hemophagocytic lymphohistiocytosis case with newly defined UNC13D (C.175G>C; p.Ala59Pro) mutation and a rare complication | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 32 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 355 | en_US |
dc.identifier.endpage | 358 | en_US |
dc.identifier.doi | 10.4274/tjh.2014.0416 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 26377049 | en_US |
dc.identifier.scopus | 2-s2.0-84948751403 | en_US |
dc.identifier.trdizinid | 194973 | en_US |
dc.identifier.wos | WOS:000369120000011 | en_US |
dc.identifier.scopusquality | Q4 | - |
dc.owner | Pamukkale University | - |
item.grantfulltext | open | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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yasemin ışık balcı.pdf | 215.46 kB | Adobe PDF | View/Open |
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