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https://hdl.handle.net/11499/10383
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DC Field | Value | Language |
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dc.contributor.author | Ayada, C. | - |
dc.contributor.author | Turgut, Günfer | - |
dc.contributor.author | Turgut, S. | - |
dc.date.accessioned | 2019-08-16T13:17:12Z | |
dc.date.available | 2019-08-16T13:17:12Z | |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0006-9248 | - |
dc.identifier.uri | https://hdl.handle.net/11499/10383 | - |
dc.identifier.uri | https://doi.org/10.4149/BLL_2015_061 | - |
dc.description.abstract | Background: Elevated L-type Ca2+ channel expression level increases Ca2+ influx. This can cause hypertrophy and pathological remodeling of the heart especially under stress conditions. Nesfatin-1 can activate hypothalamic L, P and Q type Ca2+ channels and increase insulin secretion in pancreatic islet beta cells via activation of L-type Ca2+ channels. On the other hand, the effect of nesfatin-1 on cardiac L-type Ca2+ channels has not been studied yet. Objectives: We aimed to identify the effect of peripheral chronic nesfatin-1 application on cardiac L-type Ca2+ channel ?1c subunit expression level in normal rats and those subjected to chronic restraint stress. Methods: Three-month aged Wistar albino rats were randomly divided into 4 groups (n = 7) as Control, Stress, Control+Nesfatin-1, and Nesfatin-1+Stress. Rats in groups subjected to restraint stress were placed in a specially built size-manipulable cabin for 2 h/day (between 10:00 and 12:00 a.m.) for 10 consecutive days without allowing water and food intake. Nesfatin-1 segment (0.25 nmol/g bw intraperitoneally) was applied during the 10 consecutive days. Western blot analyses were performed to determine the expression level of L-type Ca2+ channel ?1c subunit protein in rat cardiac extracts. Results: Cardiac L-type Ca2+ channel ?1c subunit protein expression levels were increased significantly after chronic peripheral nesfatin-1 application in rats subjected to restraint stress (p = 0.032). Conclusion: We can conclude that nesfatin-1 can cause cardiac failures during clinical treatments by elevating cardiac L-type Ca2+ channel ?1c subunit protein expression level (Fig. 2, Ref. 26). Text in PDF www.elis.sk. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Comenius University | en_US |
dc.relation.ispartof | Bratislava Medical Journal | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cardiac failure | en_US |
dc.subject | Chronic restraint stress | en_US |
dc.subject | L-type Ca2+ channel ?1c subunit | en_US |
dc.subject | Nesfatin-1 | en_US |
dc.subject | Western blot | en_US |
dc.subject | Cacna1c protein, rat | en_US |
dc.subject | calcium binding protein | en_US |
dc.subject | calcium channel L type | en_US |
dc.subject | DNA binding protein | en_US |
dc.subject | nerve protein | en_US |
dc.subject | nucleobindin | en_US |
dc.subject | animal | en_US |
dc.subject | drug effects | en_US |
dc.subject | exercise | en_US |
dc.subject | heart | en_US |
dc.subject | heart muscle | en_US |
dc.subject | male | en_US |
dc.subject | mental stress | en_US |
dc.subject | metabolism | en_US |
dc.subject | rat | en_US |
dc.subject | Wistar rat | en_US |
dc.subject | Animals | en_US |
dc.subject | Calcium Channels, L-Type | en_US |
dc.subject | Calcium-Binding Proteins | en_US |
dc.subject | DNA-Binding Proteins | en_US |
dc.subject | Heart | en_US |
dc.subject | Male | en_US |
dc.subject | Myocardium | en_US |
dc.subject | Nerve Tissue Proteins | en_US |
dc.subject | Rats | en_US |
dc.subject | Rats, Wistar | en_US |
dc.subject | Restraint, Physical | en_US |
dc.subject | Stress, Psychological | en_US |
dc.title | The effect of nesfatin-1 on heart L-type Ca2+ channel a?1c subunit in rats subjected to chronic restraint stress | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 116 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 326 | |
dc.identifier.startpage | 326 | en_US |
dc.identifier.endpage | 329 | en_US |
dc.identifier.doi | 10.4149/BLL_2015_061 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 25924643 | en_US |
dc.identifier.scopus | 2-s2.0-84928743585 | en_US |
dc.identifier.wos | WOS:000357840200008 | en_US |
dc.identifier.scopusquality | Q3 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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Effect.pdf | 303.38 kB | Adobe PDF | View/Open |
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