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https://hdl.handle.net/11499/10478
Title: | Q192R and L55M polymorphisms of paraoxonase 1 gene in chronic myelogenous leukemia and chronic lymphocytic leukemia | Authors: | Tomatir, Ayşe Gaye Pehlivan, S. Sahin, H.H. Balci, S.O. Budeyri, S. Pehlivan, M. |
Keywords: | Chronic lymphocytic leukemia (CLL) Chronic myeoloid leukemia (CML) L55M polymorphism Paraoxonase-1 (PON1) PCR-RFLP Q192R polymorphism agarose aryldialkylphosphatase 1 aryldialkylphosphatase PON1 protein, human adult aged allele Article cancer patient chronic lymphatic leukemia chronic myeloid leukemia controlled study female gene frequency genotype human major clinical study male polymerase chain reaction priority journal restriction fragment length polymorphism statistical significance Turkish citizen adolescent case control study genetic predisposition genetics middle aged single nucleotide polymorphism young adult Adolescent Adult Aged Aryldialkylphosphatase Case-Control Studies Female Genetic Predisposition to Disease Humans Leukemia, Lymphocytic, Chronic, B-Cell Leukemia, Myelogenous, Chronic, BCR-ABL Positive Male Middle Aged Polymorphism, Single Nucleotide Young Adult |
Publisher: | International Institute of Anticancer Research | Abstract: | Aim: The aim of the present study was to investigate the association between Paraoxonase 1 (PON1) gene polymorphisms Q192R, and L55M in patients with Chronic Myelogenous Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL) patients. Materials and Methods: We analyzed samples from 60 patients with CML, 60 with CLL and 84 healthy controls. Polymerase Chain Reaction (PCR) - Restriction Fragment Length Polymorphism (RLFP) was performed and samples were run in agarose gel. Results: We found statistically significant results showing an increase in both the RR genotype (p=0.044) and the R allele (p=0.011) for PON1 Q192R, and an increase in the MM genotype (p=0.007) and a decrease in the LL genotype (p=0.004) and R allele (p=0.001) in PON1 L55M in patients with CLL. Conclusion: We concluded that both the Q192R gene polymorphism with an increase in the genotype R allele, and the M/L55 with an increase in the MM genotype play a role in CLL susceptibility, and a decrease in the LL genotype can act against disease in the Turkish population. | URI: | https://hdl.handle.net/11499/10478 | ISSN: | 0250-7005 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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