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https://hdl.handle.net/11499/10490
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tiryakioglu, O. | - |
dc.contributor.author | Erkoc, K. | - |
dc.contributor.author | Tunerir, B. | - |
dc.contributor.author | Uysal, O. | - |
dc.contributor.author | Altin, H.F. | - |
dc.contributor.author | Güneş, Tevfik | - |
dc.contributor.author | Aydin, S. | - |
dc.date.accessioned | 2019-08-16T13:19:33Z | |
dc.date.available | 2019-08-16T13:19:33Z | |
dc.date.issued | 2015 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | https://hdl.handle.net/11499/10490 | - |
dc.identifier.uri | https://doi.org/10.1155/2015/453748 | - |
dc.description.abstract | Objective. The objective of this study was to examine the effects of iloprost and N-acetylcysteine (NAC) on ischemia-reperfusion (IR) injuries to the gastrocnemius muscle, following the occlusion-reperfusion period in the abdominal aorta of rats. Materials and Methods. Forty male Sprague-Dawley rats were randomly divided into four equal groups. Group 1: control group. Group 2 (IR): aorta was occluded. The clamp was removed after 1 hour of ischemia. Blood samples and muscle tissue specimens were collected following a 2-hour reperfusion period. Group 3 (IR + iloprost): during a 1-hour ischemia period, iloprost infusion was initiated from the jugular catheter. During a 2-hour reperfusion period, the iloprost infusion continued. Group 4 (IR + NAC): similar to the iloprost group. Findings. The mean total oxidant status, CK, and LDH levels were highest in Group 2 and lowest in Group 1. The levels of these parameters in Group 3 and Group 4 were lower compared to Group 2 and higher compared to Group 1 (P < 0.05). The histopathological examination showed that Group 3 and Group 4, compared to Group 2, had preserved appearance with respect to hemorrhage, necrosis, loss of nuclei, infiltration, and similar parameters. Conclusion. Iloprost and NAC are effective against ischemia-reperfusion injury and decrease ischemia-related tissue injury. © 2015 Osman Tiryakioglu et al. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Hindawi Publishing Corporation | en_US |
dc.relation.ispartof | BioMed Research International | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | 2,2' azinobis(3 ethylbenzothiazoline 6 sulfonic acid) | en_US |
dc.subject | acetylcysteine | en_US |
dc.subject | creatine kinase | en_US |
dc.subject | iloprost | en_US |
dc.subject | lactate dehydrogenase | en_US |
dc.subject | reactive oxygen metabolite | en_US |
dc.subject | abdominal aorta | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | animal tissue | en_US |
dc.subject | Article | en_US |
dc.subject | cell infiltration | en_US |
dc.subject | cell swelling | en_US |
dc.subject | controlled study | en_US |
dc.subject | experimental study | en_US |
dc.subject | gastrocnemius muscle | en_US |
dc.subject | heart muscle ischemia | en_US |
dc.subject | histopathology | en_US |
dc.subject | loading drug dose | en_US |
dc.subject | macrophage | en_US |
dc.subject | male | en_US |
dc.subject | monocyte | en_US |
dc.subject | nonhuman | en_US |
dc.subject | rat | en_US |
dc.subject | reperfusion injury | en_US |
dc.subject | animal | en_US |
dc.subject | drug effects | en_US |
dc.subject | human | en_US |
dc.subject | injuries | en_US |
dc.subject | pathology | en_US |
dc.subject | skeletal muscle | en_US |
dc.subject | Sprague Dawley rat | en_US |
dc.subject | Rattus | en_US |
dc.subject | Acetylcysteine | en_US |
dc.subject | Animals | en_US |
dc.subject | Aorta, Abdominal | en_US |
dc.subject | Humans | en_US |
dc.subject | Iloprost | en_US |
dc.subject | Male | en_US |
dc.subject | Muscle, Skeletal | en_US |
dc.subject | Rats | en_US |
dc.subject | Rats, Sprague-Dawley | en_US |
dc.subject | Reperfusion Injury | en_US |
dc.title | The effect of iloprost and n-acetylcysteine on skeletal muscle injury in an acute aortic ischemia-reperfusion model: An experimental study | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 2015 | en_US |
dc.identifier.doi | 10.1155/2015/453748 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 25834818 | en_US |
dc.identifier.scopus | 2-s2.0-84925326247 | en_US |
dc.identifier.wos | WOS:000351371300001 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 06.01. Clinical Sciences | - |
crisitem.author.dept | 08.02. Political Science and Public Administration | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Size | Format | |
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The Effect of Iloprost.pdf | 3.96 MB | Adobe PDF | View/Open |
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