Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10511
Title: Clinical characteristics, post-treatment assessment and prognostic factors affecting patient survival of patients at 65 years of age or older with hodgkin lymphoma: A retrospective multicenter study from Turkey
Authors: Berber, İlhami
Erkurt, Mehmet Ali
Keklik, Muzaffer
Doğu, Mehmet Hilmi
Terzi, Hatice
Sarı, Hakan İsmail
İlhan, Osman
Eser, Bülent
Kaya, Emin
Korkmaz, Serdal
Keywords: Elderly patients
Hodgkin lymphoma
Prognostic factors
bleomycin
carboplatin
chlormethine
cisplatin
cytarabine
dacarbazine
dexamethasone
doxorubicin
etoposide
ferritin
ifosfamide
prednisone
procarbazine
protein
vinblastine
vincristine
aged
aging
Article
autologous stem cell transplantation
cancer patient
cancer survival
clinical article
clinical feature
comorbidity
drug megadose
fatality
Hodgkin disease
human
lymphocyte-rich classical Hodgkin lymphoma
multicenter study (topic)
multiple cycle treatment
nodular lymphocyte predominant Hodgkin lymphoma
overall survival
post treatment survival
prognosis
progression free survival
retrospective study
sedimentation rate
treatment outcome
Turkey (republic)
Publisher: A. CARBONE Editore
Abstract: Introduction: During the last three decades, major advances have been made in the therapy of Hodgkin's lymphoma. However, despite these advances, Hodgkin's lymphoma has a poor prognosis in the elderly. The proportion of Hodgkin's lymphoma patients aged > 60 ranges in the different reports between 15% and 35%. This study aimed to examine clinical characteristics, treatment outcomes and prognostic factors affecting patient survival in Hodgkin's lymphoma patients aged 65 years or older. Material methods: Hodgkin's lymphoma patients at 65 years of age and older managed within last 5 years in a total of 5 centers in Turkey were retrospectively assessed. Results: The median age of a total of 32 patients was 71 (65-83) years. Elderly patients presented more frequently with B symptoms, elevated sedimentation rate, mixed cellularity histologic subtype and comorbid disease. Less frequent were bulky disease, bone marrow involvement, and the application of autologous stem cell transplantation. The nodular lymphocyte predominant subtype and lymphocyte rich subtype were not observed at all. Eastern Cooperative Oncology Group, ferritin, total protein, and histological type were significant predictors affecting survival (p<0.05). Conclusions: Hodgkin's lymphoma is a more fatal disease in 65 years of age or older, when compared to the young population. Tumor biology, older age itself, and other factors related to comorbidity probably contribute to the worse outcome of elderly patients. Further large-scale studies are needed to better investigate the factors that were significant predictors of patient survival.
URI: https://hdl.handle.net/11499/10511
ISSN: 0393-6384
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File SizeFormat 
document (15).pdf245.71 kBAdobe PDFView/Open
Show full item record



CORE Recommender

Page view(s)

58
checked on Aug 24, 2024

Download(s)

12
checked on Aug 24, 2024

Google ScholarTM

Check





Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.