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https://hdl.handle.net/11499/10511
Title: | Clinical characteristics, post-treatment assessment and prognostic factors affecting patient survival of patients at 65 years of age or older with hodgkin lymphoma: A retrospective multicenter study from Turkey | Authors: | Berber, İlhami Erkurt, Mehmet Ali Keklik, Muzaffer Doğu, Mehmet Hilmi Terzi, Hatice Sarı, Hakan İsmail İlhan, Osman Eser, Bülent Kaya, Emin Korkmaz, Serdal |
Keywords: | Elderly patients Hodgkin lymphoma Prognostic factors bleomycin carboplatin chlormethine cisplatin cytarabine dacarbazine dexamethasone doxorubicin etoposide ferritin ifosfamide prednisone procarbazine protein vinblastine vincristine aged aging Article autologous stem cell transplantation cancer patient cancer survival clinical article clinical feature comorbidity drug megadose fatality Hodgkin disease human lymphocyte-rich classical Hodgkin lymphoma multicenter study (topic) multiple cycle treatment nodular lymphocyte predominant Hodgkin lymphoma overall survival post treatment survival prognosis progression free survival retrospective study sedimentation rate treatment outcome Turkey (republic) |
Publisher: | A. CARBONE Editore | Abstract: | Introduction: During the last three decades, major advances have been made in the therapy of Hodgkin's lymphoma. However, despite these advances, Hodgkin's lymphoma has a poor prognosis in the elderly. The proportion of Hodgkin's lymphoma patients aged > 60 ranges in the different reports between 15% and 35%. This study aimed to examine clinical characteristics, treatment outcomes and prognostic factors affecting patient survival in Hodgkin's lymphoma patients aged 65 years or older. Material methods: Hodgkin's lymphoma patients at 65 years of age and older managed within last 5 years in a total of 5 centers in Turkey were retrospectively assessed. Results: The median age of a total of 32 patients was 71 (65-83) years. Elderly patients presented more frequently with B symptoms, elevated sedimentation rate, mixed cellularity histologic subtype and comorbid disease. Less frequent were bulky disease, bone marrow involvement, and the application of autologous stem cell transplantation. The nodular lymphocyte predominant subtype and lymphocyte rich subtype were not observed at all. Eastern Cooperative Oncology Group, ferritin, total protein, and histological type were significant predictors affecting survival (p<0.05). Conclusions: Hodgkin's lymphoma is a more fatal disease in 65 years of age or older, when compared to the young population. Tumor biology, older age itself, and other factors related to comorbidity probably contribute to the worse outcome of elderly patients. Further large-scale studies are needed to better investigate the factors that were significant predictors of patient survival. | URI: | https://hdl.handle.net/11499/10511 | ISSN: | 0393-6384 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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