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https://hdl.handle.net/11499/10563
Title: | An evaluation of the differences in DNA damage in lymphocytes and repair efficiencies in patients with schizophrenia and schizoaffective disorder | Authors: | Topak, Osman Zülkif Özdel, Osman İsmail Dodurga, Y. Secme, M. |
Keywords: | DNA damage DNA repair Schizoaffective disorder Schizophrenia amisulpride biperiden clozapine olanzapine paliperidone quetiapine risperidone valproic acid adult Article comet assay controlled study disease duration drug response enzyme linked immunosorbent assay female gene gene expression human lymphocyte major clinical study male NEIL1 gene OGG1 gene oxidative stress priority journal real time polymerase chain reaction risk factor schizoaffective psychosis schizophrenia smoking |
Publisher: | Elsevier B.V. | Abstract: | Schizophrenia and schizoaffective disorder are chronic and debilitating psychiatric disorders. The present study was designed to determine DNA damage in patients with schizophrenia and schizoaffective disorder to assess the roles of oxidative metabolism and DNA repair mechanisms in this process, to assess the contribution of drugs, and thus to demonstrate the differences between schizophrenia and schizoaffective disorder. Thirty schizophrenia and 30 schizoaffective disorder patients, each having at least five years of disease history, aged between 18 and 60 years with no physical or neurological diseases, and 30 healthy volunteers participated in the study. Psychometric scales were applied, and 5 ml of blood was taken from all participants. The DNA damage was measured in lymphocytes by the comet assay method; the total oxidative parameters by ELISA; OGG1 and NEIL1 gene expressions by real-time PCR; and the role of drugs by in vitro assays. The most important finding in this study was that patients with schizophrenia had significantly greater DNA damage than schizoaffective disorder patients and the controls. This study also provides evidence of high oxidative stress statuses and inadequate DNA repair capacities in patients with schizophrenia. Moreover, psychotropic drugs did not induce any DNA damage to the lymphocytes according to in vitro analyses. The use of clozapine and adequate repair processes of the patients were the decisive factors in the prevention of DNA damage. The results of this study provide a reexamination of schizoaffective disorder within the schizophrenia spectrum and indicate that schizoaffective disorder may be considered a different diagnostic category. © 2018 Elsevier B.V. | URI: | https://hdl.handle.net/11499/10563 https://doi.org/10.1016/j.schres.2018.06.052 |
ISSN: | 0920-9964 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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