Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10563
Title: An evaluation of the differences in DNA damage in lymphocytes and repair efficiencies in patients with schizophrenia and schizoaffective disorder
Authors: Topak, Osman Zülkif
Özdel, Osman İsmail
Dodurga, Y.
Secme, M.
Keywords: DNA damage
DNA repair
Schizoaffective disorder
Schizophrenia
amisulpride
biperiden
clozapine
olanzapine
paliperidone
quetiapine
risperidone
valproic acid
adult
Article
comet assay
controlled study
disease duration
drug response
enzyme linked immunosorbent assay
female
gene
gene expression
human
lymphocyte
major clinical study
male
NEIL1 gene
OGG1 gene
oxidative stress
priority journal
real time polymerase chain reaction
risk factor
schizoaffective psychosis
schizophrenia
smoking
Publisher: Elsevier B.V.
Abstract: Schizophrenia and schizoaffective disorder are chronic and debilitating psychiatric disorders. The present study was designed to determine DNA damage in patients with schizophrenia and schizoaffective disorder to assess the roles of oxidative metabolism and DNA repair mechanisms in this process, to assess the contribution of drugs, and thus to demonstrate the differences between schizophrenia and schizoaffective disorder. Thirty schizophrenia and 30 schizoaffective disorder patients, each having at least five years of disease history, aged between 18 and 60 years with no physical or neurological diseases, and 30 healthy volunteers participated in the study. Psychometric scales were applied, and 5 ml of blood was taken from all participants. The DNA damage was measured in lymphocytes by the comet assay method; the total oxidative parameters by ELISA; OGG1 and NEIL1 gene expressions by real-time PCR; and the role of drugs by in vitro assays. The most important finding in this study was that patients with schizophrenia had significantly greater DNA damage than schizoaffective disorder patients and the controls. This study also provides evidence of high oxidative stress statuses and inadequate DNA repair capacities in patients with schizophrenia. Moreover, psychotropic drugs did not induce any DNA damage to the lymphocytes according to in vitro analyses. The use of clozapine and adequate repair processes of the patients were the decisive factors in the prevention of DNA damage. The results of this study provide a reexamination of schizoaffective disorder within the schizophrenia spectrum and indicate that schizoaffective disorder may be considered a different diagnostic category. © 2018 Elsevier B.V.
URI: https://hdl.handle.net/11499/10563
https://doi.org/10.1016/j.schres.2018.06.052
ISSN: 0920-9964
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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