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https://hdl.handle.net/11499/10592
Title: | The beneficial effects of nerolidol and hesperidin on surgically induced endometriosis in a rat model* | Authors: | Melekoglu, R. Çiftçi, Osman Eraslan, S. Cetin, A. Basak, N. |
Keywords: | Anti-inflammatory agents; endometriosis hesperidin nerolidol oxidative stress glutathione glutathione peroxidase malonaldehyde superoxide dismutase adult animal experiment animal model antioxidant activity Article cell infiltration comparative study controlled study drug effect endometriosis enzyme activity female histopathology inflammatory cell nonhuman priority journal rat tissue homogenate treatment duration uterus horn |
Publisher: | Taylor and Francis Ltd | Abstract: | The objective of this article is to analyze the effects of nerolidol and hesperidin treatment on surgically induced endometriosis in a rat model. Endometriosis was induced in 24 healthy adult female Wistar albino rats via homologous uterine horn transplantation. Three operations were performed on each rat. After the second operation, the rats were randomized into control, nerolidol, and hesperidin treatment groups, and medications were administered for 2 weeks. The effects of the drugs on the endometriotic foci were evaluated after the third operation. Compared with the endometriosis control group, the average volume of the lesions was significantly lower in rats treated with hesperidin and nerolidol. Malondialdehyde levels were significantly reduced in the nerolidol-treated group, and glutathione levels and superoxide dismutase activity were significantly elevated in the endometriotic foci of both the hesperidin- and nerolidol-treated groups compared with the endometriosis group. Hesperidin and nerolidol treatment also improved histological parameters, such as hemorrhage, vascular congestion, necrosis, and inflammatory cell infiltration in the endometriotic foci. The results of this study demonstrated that treatment with the potent antioxidants nerolidol and hesperidin caused a significant regression of surgically induced endometriotic foci in rats. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. | URI: | https://hdl.handle.net/11499/10592 https://doi.org/10.1080/09513590.2018.1469611 |
ISSN: | 0951-3590 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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