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https://hdl.handle.net/11499/10615
Title: | Plaque burden influences accurate classification of fibrous cap atheroma by in vivo optical coherence tomography in a porcine model of advanced coronary atherosclerosis | Authors: | Poulsen, C.B. Pedrigi, R.M. Pareek, N. Kılıç, İsmail Doğu Holm, N.R. Bentzon, J.F. Bøtker, H.E. |
Keywords: | Coronary artery disease Optical coherence tomography Preclinical research iohexol animal experiment animal model animal tissue Article atheroma coronary angiography coronary artery atherosclerosis disease burden disease classification female fibrous cap atheroma histopathology hypercholesterolemia image analysis image processing image reconstruction lipid diet nonhuman optical coherence tomography sensitivity and specificity transgenic pig Yucatan micropig |
Publisher: | EuroPCR | Abstract: | Aims: In vivo validation of coronary optical coherence tomography (OCT) against histology and the effects of plaque burden (PB) on plaque classification remain unreported. We aimed to investigate this in a porcine model with human-like coronary atherosclerosis. Methods and results: Five female Yucatan D374Y-PCSK9 transgenic hypercholesterolaemic minipigs were implanted with a coronary shear-modifying stent to induce advanced atherosclerosis. OCT frames (n=201) were obtained 34 weeks after implantation. Coronary arteries were perfusion-fixed, serially sectioned and co-registered with OCT using a validated algorithm. Lesions were adjudicated using the Virmani classification and PB assessed from histology. OCT had a high sensitivity, but modest specificity (92.9% and 74.6%), for identifying fibrous cap atheroma (FCA). The reduced specificity for OCT was due to mis-classification of plaques with histologically defined pathological intimal thickening (PIT) as FCA (46.1% of the frames with histological PIT were misclassified). PIT lesions misclassified as FCA by OCT had a statistically higher PB than in other OCT frames (median 32.0% versus 13.4%; p<0.0001). Misclassification of PIT lesions by OCT occurred when PB exceeded approximately 20%. Conclusions: Compared with histology, in vivo OCT classification of FCA had high sensitivity but reduced specificity due to misclassification of PITs with high PB. © Europa Digital & Publishing 2018. All rights reserved. | URI: | https://hdl.handle.net/11499/10615 https://doi.org/10.4244/EIJ-D-17-01028 |
ISSN: | 1774-024X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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