Evaluation of the relationship between TNF?, sTNFR1, sTNFR2, sIL2R, IL6, neopterin with disease activity in ankylosing spondylitis

Abstract

Objective: We aimed to evaluate the relationship among TNF?, sTNFR1, sTNFR2, sIL2R, IL6, neopterin and disease activity in ankylosing spondylitis (AS). Materials and methods: TNF?, sTNFR1, sTNFR2, sIL2R, IL6 and neopterin were measured in patients and controls. Patients were grouped according to disease activity and medication. Results: Neopterin and sTNFR1 were not different while TNF?, sTNFR2, sIL2R and IL6 were high in patients than controls. There was no difference between active and inactive patients for TNF?, sIL2R and IL6. sTNFR2 was significantly lower in active patients. There was no relationship between CRP positivity and disease activity. AS patient groups are; 1: TNF blockers, 2: nonsteroidal antiinflammatory drugs (NSAIDs), 3: Disease modifying antirheumatic drugs (DMARDs), 4: TNF blockers and NSAIDs, 5: DMARDs and NSAIDs. sTNFR2 was significantly lower in active patients than in inactive, in Group 1. ESR levels were significantly lower in inactive patients compared to active in group 3 and 4. There was no significant association between CRP positivity and disease activity. Conclusion: According to our study, CRP is insufficient in evaluating AS disease activity. ESR can be useful in evaluating the disease activity. sTNFR2 might be useful as a biological indicator of disease activity in AS treated with TNF inhibitors alone. © 2018 Turkish Biochemistry Society. All rights reserved.