Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10641
Title: Altered levels of brain-derived neurotrophic factor, proBDNF and tissue plasminogen activator in children with posttraumatic stress disorder
Authors: Aksu, Sehra
Ünlü, Gülşen
Kardeşler, Ayşen Çetin
Çakaloz, Burcu
Aybek, Hülya
Keywords: brain derived neurotrophic factor
pro brain derived neurotrophic factor
tissue plasminogen activator
unclassified drug
BDNF protein, human
PLAT protein, human
adolescent
adult
Article
child
child sexual abuse
clinical article
Clinician Administered Post Traumatic Stress Disorder Scale for Children and Adolescents
controlled study
disease severity
female
human
male
mental disease assessment
pathogenesis
posttraumatic stress disorder
priority journal
protein blood level
school child
symptom
young adult
blood
case control study
psychology
Adolescent
Brain-Derived Neurotrophic Factor
Case-Control Studies
Child
Child Abuse, Sexual
Female
Humans
Stress Disorders, Post-Traumatic
Tissue Plasminogen Activator
Publisher: Elsevier Ireland Ltd
Abstract: The current study aims to compare the serum brain-derived neurotrophic factor (BDNF), proBDNF and tissue plasminogen activator (tPA) levels in cases that have developed posttraumatic stress disorder (PTSD) in consequence of sexual abuse with those in healthy control subjects. Thirty-one female patients between 8 and 18 years of age who have been diagnosed with PTSD due to sexual abuse and thirty-one healthy female volunteer controls were included in the study. Frequency, intensity and severity of PTSD symptoms were assessed on the basis of Clinician-Administered Post-Traumatic Stress Disorder Scale for Children and Adolescents (CAPS-CA). Serum BDNF, proBDNF and tPA levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. Results of the present study revealed that serum levels of BDNF and proBDNF in PTSD group were significantly lower but tPA level was significantly higher as compared to healthy control subjects. There were no correlations between CAPS-CA scores and BDNF, proBDNF and tPA levels. Decreased levels of BDNF, as suggested to have a role in the etiopathogenesis of PTSD, appear to be a result of the reduction in proBDNF production. The increased tPA levels in such cases, on the other hand, can be a compensatory mechanism serving to increase the BDNF levels. © 2018
URI: https://hdl.handle.net/11499/10641
https://doi.org/10.1016/j.psychres.2018.07.013
ISSN: 0165-1781
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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