Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10646
Title: Quantitative assessment of macular contraction and vitreoretinal interface alterations in diabetic macular edema treated with intravitreal anti-VEGF injections
Authors: Çetin, Ebru Nevin
Demirtaş, Önder
Özbakış, N.C.
Pekel, Gökhan
Keywords: Anti-VEGF
Diabetic macular edema
Epiretinal membrane
Macular contraction
Macular vessel displacement
Vitreoretinal interface
aflibercept
hemoglobin A1c
ranibizumab
angiogenesis inhibitor
bevacizumab
vasculotropin A
adult
Article
best corrected visual acuity
central macular thickness
clinical article
controlled study
diabetic macular edema
diabetic patient
disease duration
female
follow up
human
intraocular pressure
male
middle aged
priority journal
quantitative diagnosis
retina
retina capillary
retrospective study
spectral domain optical coherence tomography
vitreoretinal interface
vitreous body
antagonists and inhibitors
complication
diabetic retinopathy
intravitreal drug administration
macular edema
optical coherence tomography
pathology
retina blood vessel
retina macula lutea
treatment outcome
visual acuity
Angiogenesis Inhibitors
Bevacizumab
Diabetic Retinopathy
Female
Follow-Up Studies
Humans
Intravitreal Injections
Macula Lutea
Macular Edema
Male
Middle Aged
Ranibizumab
Retinal Vessels
Retrospective Studies
Tomography, Optical Coherence
Treatment Outcome
Vascular Endothelial Growth Factor A
Visual Acuity
Vitreous Body
Publisher: Springer Verlag
Abstract: Background: Macular contraction after anti-vascular endothelial growth factor (anti-VEGF) injections for diabetic macular edema (DME) was evaluated by documenting the displacement of macular capillary vessels and epiretinal membrane (ERM) formation. Methods: A total of 130 eyes were included in this retrospective study. The study group consisted of 63 eyes which had intravitreal anti-VEGF injections for DME, and the control group included 67 eyes without central DME. The study and the control groups were well balanced in terms of diabetes duration and HbA1c. The distances between the bifurcation of the macular capillary retinal vessels were measured, and ERM status was evaluated based on spectral-OCT findings on the initial and final visit. Results: In the study group, the mean number of injections was 4.7 ± 2.6 (3–14). The mean follow-up time was 16.7 ± 7.8 months in the study group whereas it was 20.7 ± 10.9 months in the control group (p = 0.132). The change in distance measurements between the reference points on macular capillary vessels was significant in all lines except line c (p < 0.05 for lines a, b, d, e, and f) in the study group whereas it was significant in only line e in the control group (p = 0.007, paired samples test). However, when the change in macular thickness was accounted as a confounding factor, the change in distances between the references points from the initial visit to the final visit lost its significance (repeated measures ANCOVA, p > 0.05). During follow-up, the number of cases with ERM changed from 10 to 12 in the study group whereas it remained three in the control group. Conclusion: There was a displacement of macular capillary vessels which was associated with the change in macular thickness in eyes having anti-VEGF injections for DME. The number of ERM cases did not change significantly during the follow-up. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
URI: https://hdl.handle.net/11499/10646
https://doi.org/10.1007/s00417-018-4042-5
ISSN: 0721-832X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

3
checked on Sep 30, 2024

WEB OF SCIENCETM
Citations

2
checked on Sep 24, 2024

Page view(s)

46
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.