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https://hdl.handle.net/11499/10646
Title: | Quantitative assessment of macular contraction and vitreoretinal interface alterations in diabetic macular edema treated with intravitreal anti-VEGF injections | Authors: | Çetin, Ebru Nevin Demirtaş, Önder Özbakış, N.C. Pekel, Gökhan |
Keywords: | Anti-VEGF Diabetic macular edema Epiretinal membrane Macular contraction Macular vessel displacement Vitreoretinal interface aflibercept hemoglobin A1c ranibizumab angiogenesis inhibitor bevacizumab vasculotropin A adult Article best corrected visual acuity central macular thickness clinical article controlled study diabetic macular edema diabetic patient disease duration female follow up human intraocular pressure male middle aged priority journal quantitative diagnosis retina retina capillary retrospective study spectral domain optical coherence tomography vitreoretinal interface vitreous body antagonists and inhibitors complication diabetic retinopathy intravitreal drug administration macular edema optical coherence tomography pathology retina blood vessel retina macula lutea treatment outcome visual acuity Angiogenesis Inhibitors Bevacizumab Diabetic Retinopathy Female Follow-Up Studies Humans Intravitreal Injections Macula Lutea Macular Edema Male Middle Aged Ranibizumab Retinal Vessels Retrospective Studies Tomography, Optical Coherence Treatment Outcome Vascular Endothelial Growth Factor A Visual Acuity Vitreous Body |
Publisher: | Springer Verlag | Abstract: | Background: Macular contraction after anti-vascular endothelial growth factor (anti-VEGF) injections for diabetic macular edema (DME) was evaluated by documenting the displacement of macular capillary vessels and epiretinal membrane (ERM) formation. Methods: A total of 130 eyes were included in this retrospective study. The study group consisted of 63 eyes which had intravitreal anti-VEGF injections for DME, and the control group included 67 eyes without central DME. The study and the control groups were well balanced in terms of diabetes duration and HbA1c. The distances between the bifurcation of the macular capillary retinal vessels were measured, and ERM status was evaluated based on spectral-OCT findings on the initial and final visit. Results: In the study group, the mean number of injections was 4.7 ± 2.6 (3–14). The mean follow-up time was 16.7 ± 7.8 months in the study group whereas it was 20.7 ± 10.9 months in the control group (p = 0.132). The change in distance measurements between the reference points on macular capillary vessels was significant in all lines except line c (p < 0.05 for lines a, b, d, e, and f) in the study group whereas it was significant in only line e in the control group (p = 0.007, paired samples test). However, when the change in macular thickness was accounted as a confounding factor, the change in distances between the references points from the initial visit to the final visit lost its significance (repeated measures ANCOVA, p > 0.05). During follow-up, the number of cases with ERM changed from 10 to 12 in the study group whereas it remained three in the control group. Conclusion: There was a displacement of macular capillary vessels which was associated with the change in macular thickness in eyes having anti-VEGF injections for DME. The number of ERM cases did not change significantly during the follow-up. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. | URI: | https://hdl.handle.net/11499/10646 https://doi.org/10.1007/s00417-018-4042-5 |
ISSN: | 0721-832X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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