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https://hdl.handle.net/11499/10675
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DC Field | Value | Language |
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dc.contributor.author | Kılıç-Toprak, Emine | - |
dc.contributor.author | Kılıç-Erkek, Özgen | - |
dc.contributor.author | Abban-Mete, Gülçin | - |
dc.contributor.author | Caner, Vildan | - |
dc.contributor.author | Barış, İkbal Cansu | - |
dc.contributor.author | Turhan, G. | - |
dc.contributor.author | Küçükatay, Vural | - |
dc.date.accessioned | 2019-08-16T13:32:21Z | |
dc.date.available | 2019-08-16T13:32:21Z | |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1234-1010 | - |
dc.identifier.uri | https://hdl.handle.net/11499/10675 | - |
dc.identifier.uri | https://doi.org/10.12659/MSM.908992 | - |
dc.description.abstract | Background: We aimed to determine the effects of exercise followed by detraining on systolic blood pressure (SBP), heme oxygenase 2 (HO-2) expression, and carboxyhemoglobin (COHb) concentration in spontaneously hypertensive rats (SHR) to explain the role of carbon monoxide (CO) in this process. Material/Methods: Animals were randomized into exercised and detrained groups. Corresponding sedentary rats were grouped as Time 1–2. Swimming of 60 min/5 days/week for 10 weeks was applied. Detraining rats discontinued training for an additional 5 weeks. Gene and protein expressions were determined by real-time PCR and immunohistochemistry. Results: Aorta HO-2 histological scores (HSCORE) of hypertensive rats were lower, while SBP was higher. Swimming caused enhancement of HO-2 immunostaining in aorta endothelium and adventitia of SHR. Exercise induced elevation of blood COHb index in SHR. Synchronous BP lowering effect of exercise was observed. HO-2 mRNA expression, HSCORE, and blood COHb index were unaltered during detraining, while SBP was still low in SHR. Conclusions: CO synthesized by HO-2 at least partly plays a role in SBP regulation in the SHR-and BP-lowering effect of exercise. Regular exercise with short-term pauses may be advised to both hypertensives and individuals who are at risk. © Med Sci Monit. | en_US |
dc.language.iso | en | en_US |
dc.publisher | International Scientific Information, Inc. | en_US |
dc.relation.ispartof | Medical Science Monitor | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Aorta | en_US |
dc.subject | Heme oxygenase (Decyclizing) | en_US |
dc.subject | Inbred SHR | en_US |
dc.subject | Rats | en_US |
dc.subject | Swimming | en_US |
dc.subject | beta actin | en_US |
dc.subject | carbon monoxide | en_US |
dc.subject | carboxyhemoglobin | en_US |
dc.subject | complementary DNA | en_US |
dc.subject | heme oxygenase 2 | en_US |
dc.subject | messenger RNA | en_US |
dc.subject | peroxidase | en_US |
dc.subject | heme oxygenase | en_US |
dc.subject | adventitia | en_US |
dc.subject | aerobic exercise | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal tissue | en_US |
dc.subject | Article | en_US |
dc.subject | blood gas analysis | en_US |
dc.subject | blood pressure regulation | en_US |
dc.subject | controlled study | en_US |
dc.subject | endurance training | en_US |
dc.subject | enzyme activity | en_US |
dc.subject | essential hypertension | en_US |
dc.subject | exercise | en_US |
dc.subject | gene expression | en_US |
dc.subject | histological score | en_US |
dc.subject | immunohistochemistry | en_US |
dc.subject | immunoperoxidase staining | en_US |
dc.subject | male | en_US |
dc.subject | Morris water maze test | en_US |
dc.subject | mRNA expression level | en_US |
dc.subject | nonhuman | en_US |
dc.subject | protein expression level | en_US |
dc.subject | rat | en_US |
dc.subject | real time polymerase chain reaction | en_US |
dc.subject | RNA extraction | en_US |
dc.subject | scoring system | en_US |
dc.subject | sitting | en_US |
dc.subject | swimming | en_US |
dc.subject | systolic blood pressure | en_US |
dc.subject | training | en_US |
dc.subject | animal | en_US |
dc.subject | aorta | en_US |
dc.subject | blood pressure | en_US |
dc.subject | enzymology | en_US |
dc.subject | hypertension | en_US |
dc.subject | metabolism | en_US |
dc.subject | pathophysiology | en_US |
dc.subject | physiology | en_US |
dc.subject | randomization | en_US |
dc.subject | spontaneously hypertensive rat | en_US |
dc.subject | Wistar rat | en_US |
dc.subject | Animals | en_US |
dc.subject | Blood Pressure | en_US |
dc.subject | Carbon Monoxide | en_US |
dc.subject | Carboxyhemoglobin | en_US |
dc.subject | Heme Oxygenase (Decyclizing) | en_US |
dc.subject | Hypertension | en_US |
dc.subject | Male | en_US |
dc.subject | Physical Conditioning, Animal | en_US |
dc.subject | Random Allocation | en_US |
dc.subject | Rats, Inbred SHR | en_US |
dc.subject | Rats, Wistar | en_US |
dc.title | Contribution of heme oxygenase 2 to blood pressure regulation in response to swimming exercise and detraining in spontaneously hypertensive rats | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.startpage | 5851 | |
dc.identifier.startpage | 5851 | en_US |
dc.identifier.endpage | 5859 | en_US |
dc.identifier.doi | 10.12659/MSM.908992 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 30132448 | en_US |
dc.identifier.scopus | 2-s2.0-85053686009 | en_US |
dc.identifier.wos | WOS:000442483900002 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Size | Format | |
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Contribution of Heme.pdf | 1.25 MB | Adobe PDF | View/Open |
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