Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10743
Title: Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study
Authors: Köksal, I.
Yilmaz, G.
Parlak, M.
Demirdal, T.
Kinikli, S.
Candan, M.
Kaya, A.
Akhan, Sila
Aydogdu, Ozcan
Turgut, Hüseyin
Gurbuz, Yunus
Dagli, Ozgur
Gokal, Ahmet Ali
Guner, Rahmet
Kuruuzum, Ziya
Tarakci, Huseyin
Beslen, Nuri
Erdogan, Seda
Ozdener, Fatih
Keywords: APRI
Chronic hepatitis C infection
Fib-4
FibroTest
Forns index
Liver fibrosis
Non-invasive serum biomarkers
alanine aminotransferase
aspartate aminotransferase
biological marker
adult
aged
Article
aspartate aminotransferase blood level
chronic hepatitis C
clinical evaluation
diagnostic value
disease classification
female
human
human tissue
liver biopsy
liver fibrosis
major clinical study
male
multicenter study
observational study
open study
scoring system
sensitivity and specificity
Turkey (republic)
adolescent
area under the curve
biopsy
blood
clinical trial
complication
Hepacivirus
liver
liver cirrhosis
liver function test
middle aged
pathology
platelet count
procedures
statistics and numerical data
turkey (bird)
virology
young adult
Adolescent
Adult
Aged
Alanine Transaminase
Area Under Curve
Aspartate Aminotransferases
Biomarkers
Biopsy
Female
Hepatitis C, Chronic
Humans
Liver
Liver Cirrhosis
Liver Function Tests
Male
Middle Aged
Platelet Count
Sensitivity and Specificity
Turkey
Young Adult
Publisher: AVES İbrahim KARA
Abstract: Background/Aims: The hepatitis C virus (HCV) infection is important cause of chronic hepatitis. Liver biopsy is considered the gold standard for assessment of fibrosis but this procedure is an invasive procedure. We aimed to evaluate the diagnostic efficiency of non-invasive serum biomarkers, separately and in combinations, on liver fibrosis in treatment-naive chronic hepatitis C (CHC) patients. Materials and Methods: Two hundred and sixteen treatment-naive CHC patients were enrolled from 32 locations across Turkey in this open-labelled, non-interventional prospective observational study. FibroTest®, aspartate aminotransferase-to-platelet ratio index(APRI), aspartate aminotransferase and alanine aminotransferase ratio (AAR), fibrosis index based on four factors (FIB-4), Age-platelet(AP) index and Forns index were measured and compared with Metavir scores got from liver biopsies. Results: Data from 182 patients with baseline liver biopsy were suitable for analysis. One hundred and twenty patients (65.9%) had F0-F1 fibrosis and 62 patients (34.1%) had F2-F4 fibrosis. APRI 0.732 area under the curve(AUC) indicated advanced fibrosis with 69% sensitivity and 77% specificity. FIB-4 0.732 AUC and FibroTest 0.715 AUC indicated advanced fibrosis with 69% and 78.4% sensitivity, and 75% and 71.4% specificity, respectively. The combined use of tests also led to an increase in AUC and specificity. Combinations of FibroTest with APRI and/or FIB-4, and FIB-4 with APRI were optimal for the evaluation of liver fibrosis. Conclusion: Fibrotest, FIB-4, APRI, AP index and Forns index exhibit good diagnostic performance for determining liver fibrosis in CHC patients, and the use of at least two tests together will increase their diagnostic value still further. © Copyright 2018 by The Turkish Society of Gastroenterology.
URI: https://hdl.handle.net/11499/10743
https://doi.org/10.5152/tjg.2018.16597
ISSN: 1300-4948
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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