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https://hdl.handle.net/11499/10743
Title: | Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study | Authors: | Köksal, I. Yilmaz, G. Parlak, M. Demirdal, T. Kinikli, S. Candan, M. Kaya, A. Akhan, Sila Aydogdu, Ozcan Turgut, Hüseyin Gurbuz, Yunus Dagli, Ozgur Gokal, Ahmet Ali Guner, Rahmet Kuruuzum, Ziya Tarakci, Huseyin Beslen, Nuri Erdogan, Seda Ozdener, Fatih |
Keywords: | APRI Chronic hepatitis C infection Fib-4 FibroTest Forns index Liver fibrosis Non-invasive serum biomarkers alanine aminotransferase aspartate aminotransferase biological marker adult aged Article aspartate aminotransferase blood level chronic hepatitis C clinical evaluation diagnostic value disease classification female human human tissue liver biopsy liver fibrosis major clinical study male multicenter study observational study open study scoring system sensitivity and specificity Turkey (republic) adolescent area under the curve biopsy blood clinical trial complication Hepacivirus liver liver cirrhosis liver function test middle aged pathology platelet count procedures statistics and numerical data turkey (bird) virology young adult Adolescent Adult Aged Alanine Transaminase Area Under Curve Aspartate Aminotransferases Biomarkers Biopsy Female Hepatitis C, Chronic Humans Liver Liver Cirrhosis Liver Function Tests Male Middle Aged Platelet Count Sensitivity and Specificity Turkey Young Adult |
Publisher: | AVES İbrahim KARA | Abstract: | Background/Aims: The hepatitis C virus (HCV) infection is important cause of chronic hepatitis. Liver biopsy is considered the gold standard for assessment of fibrosis but this procedure is an invasive procedure. We aimed to evaluate the diagnostic efficiency of non-invasive serum biomarkers, separately and in combinations, on liver fibrosis in treatment-naive chronic hepatitis C (CHC) patients. Materials and Methods: Two hundred and sixteen treatment-naive CHC patients were enrolled from 32 locations across Turkey in this open-labelled, non-interventional prospective observational study. FibroTest®, aspartate aminotransferase-to-platelet ratio index(APRI), aspartate aminotransferase and alanine aminotransferase ratio (AAR), fibrosis index based on four factors (FIB-4), Age-platelet(AP) index and Forns index were measured and compared with Metavir scores got from liver biopsies. Results: Data from 182 patients with baseline liver biopsy were suitable for analysis. One hundred and twenty patients (65.9%) had F0-F1 fibrosis and 62 patients (34.1%) had F2-F4 fibrosis. APRI 0.732 area under the curve(AUC) indicated advanced fibrosis with 69% sensitivity and 77% specificity. FIB-4 0.732 AUC and FibroTest 0.715 AUC indicated advanced fibrosis with 69% and 78.4% sensitivity, and 75% and 71.4% specificity, respectively. The combined use of tests also led to an increase in AUC and specificity. Combinations of FibroTest with APRI and/or FIB-4, and FIB-4 with APRI were optimal for the evaluation of liver fibrosis. Conclusion: Fibrotest, FIB-4, APRI, AP index and Forns index exhibit good diagnostic performance for determining liver fibrosis in CHC patients, and the use of at least two tests together will increase their diagnostic value still further. © Copyright 2018 by The Turkish Society of Gastroenterology. | URI: | https://hdl.handle.net/11499/10743 https://doi.org/10.5152/tjg.2018.16597 |
ISSN: | 1300-4948 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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