Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10762
Full metadata record
DC FieldValueLanguage
dc.contributor.authorYilmaz, E.-
dc.contributor.authorMelekoglu, R.-
dc.contributor.authorÇiftçi, Osman-
dc.contributor.authorEraslan, S.-
dc.contributor.authorCetin, A.-
dc.contributor.authorBasak, N.-
dc.date.accessioned2019-08-16T13:32:50Z
dc.date.available2019-08-16T13:32:50Z
dc.date.issued2018-
dc.identifier.issn0102-8650-
dc.identifier.urihttps://hdl.handle.net/11499/10762-
dc.identifier.urihttps://doi.org/10.1590/s0102-865020180060000004-
dc.description.abstractPurpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin. © 2018, Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgiaen_US
dc.relation.ispartofActa Cirurgica Brasileiraen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectCapsaicinen_US
dc.subjectCurcuminen_US
dc.subjectCyclophosphamideen_US
dc.subjectRatsen_US
dc.subjectcapsaicinen_US
dc.subjectcatalaseen_US
dc.subjectcurcuminen_US
dc.subjectcyclophosphamideen_US
dc.subjectglutathioneen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectmalonaldehydeen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectalkylating agenten_US
dc.subjectantioxidanten_US
dc.subjectadulten_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectantioxidant activityen_US
dc.subjectArticleen_US
dc.subjectbiochemical analysisen_US
dc.subjectcell degenerationen_US
dc.subjectcell vacuoleen_US
dc.subjectcontrolled studyen_US
dc.subjectfemaleen_US
dc.subjecthistopathologyen_US
dc.subjectmicroscopyen_US
dc.subjectnonhumanen_US
dc.subjectoxidative stressen_US
dc.subjectraten_US
dc.subjecttissue injuryen_US
dc.subjectuterus diseaseen_US
dc.subjectanimalen_US
dc.subjectchemically induceden_US
dc.subjectdrug effecten_US
dc.subjectevaluation studyen_US
dc.subjectpathologyen_US
dc.subjectrandomizationen_US
dc.subjectreproducibilityen_US
dc.subjectuterusen_US
dc.subjectWistar raten_US
dc.subjectAnimalsen_US
dc.subjectAntineoplastic Agents, Alkylatingen_US
dc.subjectAntioxidantsen_US
dc.subjectCatalaseen_US
dc.subjectFemaleen_US
dc.subjectGlutathioneen_US
dc.subjectGlutathione Peroxidaseen_US
dc.subjectMalondialdehydeen_US
dc.subjectOxidative Stressen_US
dc.subjectRandom Allocationen_US
dc.subjectRats, Wistaren_US
dc.subjectReproducibility of Resultsen_US
dc.subjectSuperoxide Dismutaseen_US
dc.subjectUterine Diseasesen_US
dc.subjectUterusen_US
dc.titleThe therapeutic effects of curcumin and capsaicin against cyclophosphamide side effects on the uterus in ratsen_US
dc.typeArticleen_US
dc.identifier.volume33en_US
dc.identifier.issue6en_US
dc.identifier.startpage499
dc.identifier.startpage499en_US
dc.identifier.endpage507en_US
dc.identifier.doi10.1590/s0102-865020180060000004-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid30020311en_US
dc.identifier.scopus2-s2.0-85050481505en_US
dc.identifier.wosWOS:000438900400004en_US
dc.identifier.scopusqualityQ3-
dc.ownerPamukkale University-
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept30.04. Travel-Tourism and Entertainment Services-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Files in This Item:
File SizeFormat 
The therapeutic.pdf740.3 kBAdobe PDFView/Open
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

10
checked on Jun 29, 2024

WEB OF SCIENCETM
Citations

9
checked on Jul 10, 2024

Page view(s)

32
checked on May 27, 2024

Download(s)

10
checked on May 27, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.