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https://hdl.handle.net/11499/10775
Title: | Hemorheological dysfunction in cardiac syndrome X | Authors: | Kılıç-Toprak, Emine Yaylali, O. Yaylali, Y.T. Ozdemir, Y. Yuksel, D. Senol, H. Sengoz, T. |
Keywords: | cardiac syndrome X Erythrocyte aggregation microvascular angina plasma viscosity red blood cell deformability high density lipoprotein cholesterol immunoglobulin A immunoglobulin G immunoglobulin M low density lipoprotein cholesterol technetium 99m adult Article blood rheology cone beam computed tomography controlled study coronary angiography coronary artery disease erythrocyte aggregation erythrocyte count erythrocyte deformability female hematocrit human leukocyte count major clinical study male mean corpuscular hemoglobin mean corpuscular volume middle aged physical examination platelet count red blood cell distribution width scintigraphy syndrome X thorax pain viscometry |
Publisher: | Taylor and Francis Ltd. | Abstract: | Background: Cardiac syndrome X (CSX) is often described as angina or angina-like chest pain with a normal coronary arteriogram, yet the underlying pathophysiological mechanisms have not been fully elucidated. The aim of the current study was to determine alterations in blood rheology (erythrocyte aggregation and deformability, plasma viscosity–PV) in patients with CSX. Methods: The study comprised 26 CSX patients (55.77 ± 12.33 years) and 37 age- and sex-matched (56.32 ± 11.98 years) healthy controls. Erythrocyte aggregation and deformability were measured by an ektacytometer and PV with a rotational viscometer. Results: Erythrocyte deformability measured at 1.69 and 3.00 Pa was lower in the CSX patients compared to the controls (p =.0001 and.017, respectively). Erythrocyte aggregation index (AI) (72.758 ± 7.65 vs. 66.483 ± 6.63, p =.002) and PV measured at a shear rate of 375 s -1 (1.932 ± 0.225 vs. 1.725 ± 0.331, p =.019) were significantly higher in patients with CSX. When AI, RDW and erythrocyte deformability measured at 1.69 Pa were evaluated together, it was observed that the increase in AI and RDW augments the risk of having CSX (OR: 1.2 and 2.65, respectively), while the rise in deformability decreases this risk (OR = 0.02). Conclusions: Hemorheological impairments are associated with CSX. © 2017, © 2017 Belgian Society of Cardiology. | URI: | https://hdl.handle.net/11499/10775 https://doi.org/10.1080/00015385.2017.1373967 |
ISSN: | 0001-5385 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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