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https://hdl.handle.net/11499/10814
Title: | Stem cell mobilization kinetics in elderly patients with multiple myeloma | Authors: | Dogu, M.H. Batgi, H. Erkurt, M.A. Hacıoğlu, Sibel Tekgunduz, E. Kaya, E. Iskender, D. |
Keywords: | Apheresis Mobilization Multiple myeloma antineoplastic agent plerixafor recombinant granulocyte colony stimulating factor adult aged aging apheresis Article autologous hematopoietic stem cell transplantation cancer chemotherapy CD34 selection cell kinetics controlled study drug megadose female groups by age hematopoietic stem cell human major clinical study male middle aged multiple myeloma operation duration patient selection retrospective study stem cell mobilization procedures Aged Female Hematopoietic Stem Cell Mobilization Humans Male Multiple Myeloma |
Publisher: | Elsevier Ltd | Abstract: | In this study, we aimed to investigate whether the procedure and product kinetics differ according to age groups in advanced-age MM patients who underwent autologous HSCT. 59 patients who underwent autologous HSCT were retrospectively analyzed. Then, the patients were divided into two groups as 60–65 years and ?65 years. It was significantly lower in ?65 years group (p = 0.008) and proportionally, the procedure duration was also significantly shortened in this group (p = 0.013). Total number of collected CD34 positive stem cells was 6.20 × 106 (±3.83) in 60–65 years group while it was 5.51 × 106 (±2.48) in ?65 years group with no statistically significant difference (p = 0.825). In conclusion, there was no significant difference in terms of the number of collected CD34-positive stem cells in this study that investigates the mobilization data, procedure and product kinetics, we think that successful stem cell mobilization can be performed in appropriately selected patients regardless of age. © 2018 Elsevier Ltd | URI: | https://hdl.handle.net/11499/10814 https://doi.org/10.1016/j.transci.2018.01.010 |
ISSN: | 1473-0502 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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