Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10814
Title: Stem cell mobilization kinetics in elderly patients with multiple myeloma
Authors: Dogu, M.H.
Batgi, H.
Erkurt, M.A.
Hacıoğlu, Sibel
Tekgunduz, E.
Kaya, E.
Iskender, D.
Keywords: Apheresis
Mobilization
Multiple myeloma
antineoplastic agent
plerixafor
recombinant granulocyte colony stimulating factor
adult
aged
aging
apheresis
Article
autologous hematopoietic stem cell transplantation
cancer chemotherapy
CD34 selection
cell kinetics
controlled study
drug megadose
female
groups by age
hematopoietic stem cell
human
major clinical study
male
middle aged
multiple myeloma
operation duration
patient selection
retrospective study
stem cell mobilization
procedures
Aged
Female
Hematopoietic Stem Cell Mobilization
Humans
Male
Multiple Myeloma
Publisher: Elsevier Ltd
Abstract: In this study, we aimed to investigate whether the procedure and product kinetics differ according to age groups in advanced-age MM patients who underwent autologous HSCT. 59 patients who underwent autologous HSCT were retrospectively analyzed. Then, the patients were divided into two groups as 60–65 years and ?65 years. It was significantly lower in ?65 years group (p = 0.008) and proportionally, the procedure duration was also significantly shortened in this group (p = 0.013). Total number of collected CD34 positive stem cells was 6.20 × 106 (±3.83) in 60–65 years group while it was 5.51 × 106 (±2.48) in ?65 years group with no statistically significant difference (p = 0.825). In conclusion, there was no significant difference in terms of the number of collected CD34-positive stem cells in this study that investigates the mobilization data, procedure and product kinetics, we think that successful stem cell mobilization can be performed in appropriately selected patients regardless of age. © 2018 Elsevier Ltd
URI: https://hdl.handle.net/11499/10814
https://doi.org/10.1016/j.transci.2018.01.010
ISSN: 1473-0502
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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