Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10839
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dc.contributor.authorEgashira, N.-
dc.contributor.authorAkiyoshi, Y.-
dc.contributor.authorIba, H.-
dc.contributor.authorArai, T.-
dc.contributor.authorHatip-Al-Khatib, İzzettin-
dc.contributor.authorMishima, K.-
dc.contributor.authorIwasaki, K.-
dc.date.accessioned2019-08-16T13:33:12Z
dc.date.available2019-08-16T13:33:12Z
dc.date.issued2018-
dc.identifier.issn1347-8613-
dc.identifier.urihttps://hdl.handle.net/11499/10839-
dc.identifier.urihttps://doi.org/10.1016/j.jphs.2018.01.005-
dc.description.abstractPreviously, we reported that ovariectomy (OVX) combined with ß-amyloid peptide (Aß) impaired spatial memory by decreasing extracellular acetylcholine (ACh) levels in the dorsal hippocampus. Here, we investigated the effect of tokishakuyakusan (TSS), a Kampo medicine, on the impairment of spatial memory induced by OVX combined with Aß in rats. Repeated administration of TSS (300 mg/kg, p.o.) significantly decreased the number of errors in the eight-arm radial maze test. Though TSS had no effect on extracellular ACh levels at baseline, TSS significantly increased extracellular ACh levels in the dorsal hippocampus. These results suggest that TSS improves the impairment of spatial memory induced by OVX combined with Aß by (at least in part) increasing extracellular ACh levels in the dorsal hippocampus. © 2018 The Authorsen_US
dc.language.isoenen_US
dc.publisherJapanese Pharmacological Societyen_US
dc.relation.ispartofJournal of Pharmacological Sciencesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetylcholineen_US
dc.subjectMemoryen_US
dc.subjectOvariectomyen_US
dc.subjectTokishakuyakusanen_US
dc.subjectß-Amyloiden_US
dc.subjectacetylcholineen_US
dc.subjectamyloid beta protein[1-42]en_US
dc.subjectdonepezilen_US
dc.subjecttokishakuyaku sanen_US
dc.subjectamyloid beta proteinen_US
dc.subjectherbaceous agenten_US
dc.subjecttoki-shakuyaku-sanen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectArticleen_US
dc.subjectcontrolled studyen_US
dc.subjectdorsal hippocampusen_US
dc.subjectdrug mechanismen_US
dc.subjectfemaleen_US
dc.subjectmemory disorderen_US
dc.subjectnonhumanen_US
dc.subjectovariectomyen_US
dc.subjectradial arm maze testen_US
dc.subjectraten_US
dc.subjectspatial memoryen_US
dc.subjectanimalen_US
dc.subjectdrug effecten_US
dc.subjecthippocampusen_US
dc.subjectmaze testen_US
dc.subjectmetabolismen_US
dc.subjectpsychologyen_US
dc.subjectWistar raten_US
dc.subjectAmyloid beta-Peptidesen_US
dc.subjectAnimalsen_US
dc.subjectDrugs, Chinese Herbalen_US
dc.subjectFemaleen_US
dc.subjectHippocampusen_US
dc.subjectMaze Learningen_US
dc.subjectMemory Disordersen_US
dc.subjectRats, Wistaren_US
dc.subjectSpatial Memoryen_US
dc.titleTokishakuyakusan ameliorates spatial memory deficits induced by ovariectomy combined with ß-amyloid in ratsen_US
dc.typeArticleen_US
dc.identifier.volume136en_US
dc.identifier.issue3en_US
dc.identifier.startpage149
dc.identifier.startpage149en_US
dc.identifier.endpage154en_US
dc.identifier.doi10.1016/j.jphs.2018.01.005-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid29478713en_US
dc.identifier.scopus2-s2.0-85042301400en_US
dc.identifier.wosWOS:000429467200007en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.grantfulltextopen-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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