Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10852
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dc.contributor.authorUlus, R.-
dc.contributor.authorEsirden, İ.-
dc.contributor.authorAday, B.-
dc.contributor.authorTurgut, Gurbet Çelik-
dc.contributor.authorŞen, A.-
dc.contributor.authorKaya, M.-
dc.date.accessioned2019-08-16T13:33:26Z-
dc.date.available2019-08-16T13:33:26Z-
dc.date.issued2018-
dc.identifier.issn1054-2523-
dc.identifier.urihttps://hdl.handle.net/11499/10852-
dc.identifier.urihttps://doi.org/10.1007/s00044-017-2088-2-
dc.description.abstractIn this study we report that amino acridine intermediates 7 and 8 were obtained from the reduction of nitro acridine derivatives 5 and 6 that were synthesized via the condensation of dimedone, p-nitrobenzaldehyde with various amine derivatives, respectively. Then acridine sulfonamide hybrid compounds (9–18) were synthesized by the reaction of amino acridine 7, 8 with sulfonyl chlorides. The new hybrid compounds were characterized by FT-IR, 1H-NMR, 13C-NMR, and HRMS analyzes. The evaluation of in vitro anticholinesterase action of the synthesized compounds against AChE showed that some of them are potent inhibitors. Among them, compound 17 showed the most potent activity against AChE with an IC50 of 0.14 µM. © 2017, Springer Science+Business Media, LLC.en_US
dc.language.isoenen_US
dc.publisherBirkhauser Bostonen_US
dc.relation.ispartofMedicinal Chemistry Researchen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcridineen_US
dc.subjectAnticholinesterase activityen_US
dc.subjectSulfonamideen_US
dc.subjectTacrineen_US
dc.subject10 (4 bromophenyl) 3,3,6,6 tetramethyl 9 (4 nitrophenyl) 3,4,6,7,9,10 hexahydro acridine 1,8(2h,5h) dioneen_US
dc.subject10 (4 chlorophenyl) 3,3,6,6 tetramethyl 9 (4 nitrophenyl) 3,4,6,7,9,10 hexahydro acridine 1,8(2h,5h) dioneen_US
dc.subject4 bromo n [4 [10 (4 bromophenyl) 3,3,6,6 tetramethyl 1,8 dioxo 1,2,3,4,5,6,7,8,9,10 decahydro acridin 9 yl]phenyl]benzenesulfonamideen_US
dc.subject4 bromo n [4 [10 (4 chlorophenyl) 3,3,6,6 tetramethyl 1,8 dioxo 1,2,3,4,5,6,7,8,9,10 decahydro acridin 9 yl]phenyl]benzenesulfonamideen_US
dc.subject9 (4 aminophenyl) 10 (4 bromophenyl) 3,3,6,6 tetramethyl 3,4,6,7,9,10 hexahydro acridine 1,8(2h,5h) dioneen_US
dc.subject9 (4 aminophenyl) 10 (4 chlorophenyl) 3,3,6,6 tetramethyl 3,4,6,7,9,10 hexahydro acridine 1,8(2h,5h) dioneen_US
dc.subjectacetylcholinesteraseen_US
dc.subjectacridine derivativeen_US
dc.subjectcholinesterase inhibitoren_US
dc.subjectn [4 [10 (4 bromophenyl) 3,3,6,6 tetramethyl 1,8 dioxo 1,2,3,4,5,6,7,8,9,10 decahydro acridin 9 yl]phenyl] 2,4,6 trimethylbenzenesulfonamideen_US
dc.subjectn [4 [10 (4 bromophenyl) 3,3,6,6 tetramethyl 1,8 dioxo 1,2,3,4,5,6,7,8,9,10 decahydro acridin 9 yl]phenyl]benzenesulfonamideen_US
dc.subjectn [4 [10 (4 bromophenyl) 3,3,6,6 tetramethyl 1,8 dioxo 1,2,3,4,5,6,7,8,9,10 decahydro acridin 9 yl]phenyl]naphthalene 2 sulfonamideen_US
dc.subjectn [4 [10 (4 chlorophenyl) 3,3,6,6 tetramethyl 1,8 dioxo 1,2,3,4,5,6,7,8,9,10 decahydro acridin 9 yl]phenyl] 2,4,6 trimethylbenzenesulfonamideen_US
dc.subjectn [4 [10 (4 chlorophenyl) 3,3,6,6 tetramethyl 1,8 dioxo 1,2,3,4,5,6,7,8,9,10 decahydro acridin 9 yl]phenyl] 4 methoxybenzenesulfonamideen_US
dc.subjectn [4 [10 (4 chlorophenyl) 3,3,6,6 tetramethyl 1,8 dioxo 1,2,3,4,5,6,7,8,9,10 decahydro acridin 9 yl]phenyl] 4 methylbenzenesulfonamideen_US
dc.subjectn [4 [10 (4 chlorophenyl) 3,3,6,6 tetramethyl 1,8 dioxo 1,2,3,4,5,6,7,8,9,10 decahydro acridin 9 yl]phenyl]benzenesulfonamideen_US
dc.subjectsulfonamideen_US
dc.subjecttacrineen_US
dc.subjectunclassified drugen_US
dc.subjectAlzheimer diseaseen_US
dc.subjectArticleen_US
dc.subjectcarbon nuclear magnetic resonanceen_US
dc.subjectcholinesterase inhibitionen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug synthesisen_US
dc.subjectenzyme activityen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectIC50en_US
dc.subjectin vitro studyen_US
dc.subjectinfrared spectroscopyen_US
dc.subjectmass spectrometryen_US
dc.subjectproton nuclear magnetic resonanceen_US
dc.subjectSH-SY5Y cell lineen_US
dc.titleSynthesis of novel acridine-sulfonamide hybrid compounds as acetylcholinesterase inhibitor for the treatment of alzheimer’s diseaseen_US
dc.typeArticleen_US
dc.identifier.volume27en_US
dc.identifier.issue2en_US
dc.identifier.startpage634-
dc.identifier.startpage634en_US
dc.identifier.endpage641en_US
dc.identifier.doi10.1007/s00044-017-2088-2-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-85031397121en_US
dc.identifier.wosWOS:000424646600026en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.openairetypeArticle-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept03.01. Organic Agriculture Management-
crisitem.author.dept17.02. Biology-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Uygulamalı Bilimler Yüksekokulu Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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