Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10932
Title: New aspect for systemic effects of COPD: eye findings
Authors: Uğurlu, Erhan
Pekel, Gökhan
Altınışık, Göksel
Bozkurt, K.
Can, I.
Evyapan, F.
Keywords: choroid
COPD
eye
lung disease
retinal artery
retinal vein
carbon monoxide
adult
air puff tonometry
Article
biomicroscopy
carbon monoxide diffusion test
choroidal thickness
chronic obstructive lung disease
clinical article
controlled study
foveal thickness
human
intraocular pressure
lung function test
male
population research
priority journal
retinal arteriolar caliber
retinal nerve fiber layer thickness
retinal venular caliber
retinoscopy
sex ratio
spectral domain optical coherence tomography
subfoveal choroidal thickness
tonometry
visual acuity
cross-sectional study
female
middle aged
nerve fiber
optical coherence tomography
pathology
procedures
retina
Choroid
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Nerve Fibers
Pulmonary Disease, Chronic Obstructive
Retina
Tomography, Optical Coherence
Visual Acuity
Publisher: Blackwell Publishing Ltd
Abstract: Introduction: Chronic obstructive pulmonary disease (COPD) has multisystemic implications and comorbidities. Hypoxia and systemic inflammation are thought to involve oculary structures. In this study, our aim is to evaluate retinal nerve fiber and choroidal thickness and retinal vessel diameter using the spectral-domain optical coherence tomography (SD-OCT) in COPD subjects. Methods: Forty-three subjects diagnosed with COPD according to the Global Initiative for Chronic Obstructive Lung Disease criteria at the Pulmonology Department of Pamukkale University were enrolled in the study. All subjects underwent respiratory function testing and a carbon monoxide diffusion test. To determine hypoxic state, arterial blood gas analysis was performed. The control group consisted of 31 subjects with comparable age and gender distribution. All participants underwent a standard ophthalmic examination including visual acuity assessment, biomicroscopy, air-puff tonometry, indirect retinoscopy, and SD-OCT measurements. Results: The mean subfoveal choroidal thickness (SFCT), foveal thickness, and retinal arteriolar caliber were found to be similar in both groups, while the mean retinal venular caliber value was markedly higher in the COPD group. The mean peripapillary retinal nerve fiber layer (RNFL) thickness was 100.2±11.8 µm in the COPD group and 105.6 ± 8.1 µm in the control group (P =.03). The inferior quadrant RNFL was significantly thinner in the COPD group. Conclusions: The results of this study showed increasing diameter of the retinal veins, thinning of the RNFL, and SFCT may be associated to chronic inflammation and hypoxia in subjects with COPD. Future guidelines may include ocular findings to the present systemic manifestations of COPD. © 2016 John Wiley & Sons Ltd
URI: https://hdl.handle.net/11499/10932
https://doi.org/10.1111/crj.12523
ISSN: 1752-6981
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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