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https://hdl.handle.net/11499/10932
Title: | New aspect for systemic effects of COPD: eye findings | Authors: | Uğurlu, Erhan Pekel, Gökhan Altınışık, Göksel Bozkurt, K. Can, I. Evyapan, F. |
Keywords: | choroid COPD eye lung disease retinal artery retinal vein carbon monoxide adult air puff tonometry Article biomicroscopy carbon monoxide diffusion test choroidal thickness chronic obstructive lung disease clinical article controlled study foveal thickness human intraocular pressure lung function test male population research priority journal retinal arteriolar caliber retinal nerve fiber layer thickness retinal venular caliber retinoscopy sex ratio spectral domain optical coherence tomography subfoveal choroidal thickness tonometry visual acuity cross-sectional study female middle aged nerve fiber optical coherence tomography pathology procedures retina Choroid Cross-Sectional Studies Female Humans Male Middle Aged Nerve Fibers Pulmonary Disease, Chronic Obstructive Retina Tomography, Optical Coherence Visual Acuity |
Publisher: | Blackwell Publishing Ltd | Abstract: | Introduction: Chronic obstructive pulmonary disease (COPD) has multisystemic implications and comorbidities. Hypoxia and systemic inflammation are thought to involve oculary structures. In this study, our aim is to evaluate retinal nerve fiber and choroidal thickness and retinal vessel diameter using the spectral-domain optical coherence tomography (SD-OCT) in COPD subjects. Methods: Forty-three subjects diagnosed with COPD according to the Global Initiative for Chronic Obstructive Lung Disease criteria at the Pulmonology Department of Pamukkale University were enrolled in the study. All subjects underwent respiratory function testing and a carbon monoxide diffusion test. To determine hypoxic state, arterial blood gas analysis was performed. The control group consisted of 31 subjects with comparable age and gender distribution. All participants underwent a standard ophthalmic examination including visual acuity assessment, biomicroscopy, air-puff tonometry, indirect retinoscopy, and SD-OCT measurements. Results: The mean subfoveal choroidal thickness (SFCT), foveal thickness, and retinal arteriolar caliber were found to be similar in both groups, while the mean retinal venular caliber value was markedly higher in the COPD group. The mean peripapillary retinal nerve fiber layer (RNFL) thickness was 100.2±11.8 µm in the COPD group and 105.6 ± 8.1 µm in the control group (P =.03). The inferior quadrant RNFL was significantly thinner in the COPD group. Conclusions: The results of this study showed increasing diameter of the retinal veins, thinning of the RNFL, and SFCT may be associated to chronic inflammation and hypoxia in subjects with COPD. Future guidelines may include ocular findings to the present systemic manifestations of COPD. © 2016 John Wiley & Sons Ltd | URI: | https://hdl.handle.net/11499/10932 https://doi.org/10.1111/crj.12523 |
ISSN: | 1752-6981 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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