Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10935
Title: Intravenous dexketoprofen versus intravenous paracetamol for dysmenorrhea: A randomized controlled trial
Authors: Serinken, Mustafa
Eken, C.
Karcıoğlu, Ö.
Keywords: Dexketoprofen
Dysmenorrhea
Intravenous
Paracetamol
Treatment
arveles
dexketoprofen
paracetamol
ketoprofen
nonsteroid antiinflammatory agent
adult
Article
controlled study
dysmenorrhea
female
human
intention to treat analysis
major clinical study
menstruation
pain measurement
pain severity
pelvic pain
prospective study
randomized controlled trial
treatment outcome
visual analog scale
complication
double blind procedure
pain
young adult
Acetaminophen
Anti-Inflammatory Agents, Non-Steroidal
Double-Blind Method
Female
Humans
Ketoprofen
Pain
Prospective Studies
Young Adult
Publisher: Galenos Publishing House
Abstract: Background: Dysmenorrhea is one of the most common acute pain disorders among women of reproductive age. Aims: To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department. Study Design: Randomized controlled trial. Methods: Patients over 18 years old presenting with pelvic pain related to menstruation were eligible for the study. Study patients received 1 g paracetamol or 50 mg dexketoprofen in 100 mL normal saline with a 4-5 minute infusion via the intravenous route. Pain intensity was measured by a visual analog scale at 15 and 30 minutes. Patients were randomized and assigned to either of two study arms via sealed envelopes. Study drugs were identical in color, and thus both personnel and patients were blinded to the study drug. The dexketoprofen group comprised 49 patients, and the paracetamol group had 50 patients in the final analysis. Results: The mean age of the study subjects was 20.9±2.5 and the mean duration of the pain was 1.9±1.7 (median: 1, interquartile range: 1 to 2) hours. Both dexketoprofen (median change: 33, 95% CI: 24 to 38) and paracetamol (median change: 21, 95% CI: 12 to 32) effectively reduced the pain at 15 minutes, which was repeated at 30 minutes (median change: 63, 95% CI: 57 to 65 vs 55.5, 95% CI: 50 to 59, respectively). Pain improvement in the dexketoprofen group was better than in the paracetamol group at 15 (median difference: 8, 95% CI: 0 to 16, p=0.048) and 30 (median difference: 6, 95% CI: 1 to 12, p=0.028) minutes, which was statistically significant but not clinically significant. Conclusion: Dexketotoprofen has a better visual analogue scale score that is not clinically relevant compared to paracetamol. © 2018, Galenos Publishing House. All rights reserved.
URI: https://hdl.handle.net/11499/10935
https://doi.org/10.4274/balkanmedj.2016.0536
ISSN: 2146-3123
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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