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https://hdl.handle.net/11499/10935
Title: | Intravenous dexketoprofen versus intravenous paracetamol for dysmenorrhea: A randomized controlled trial | Authors: | Serinken, Mustafa Eken, C. Karcıoğlu, Ö. |
Keywords: | Dexketoprofen Dysmenorrhea Intravenous Paracetamol Treatment arveles dexketoprofen paracetamol ketoprofen nonsteroid antiinflammatory agent adult Article controlled study dysmenorrhea female human intention to treat analysis major clinical study menstruation pain measurement pain severity pelvic pain prospective study randomized controlled trial treatment outcome visual analog scale complication double blind procedure pain young adult Acetaminophen Anti-Inflammatory Agents, Non-Steroidal Double-Blind Method Female Humans Ketoprofen Pain Prospective Studies Young Adult |
Publisher: | Galenos Publishing House | Abstract: | Background: Dysmenorrhea is one of the most common acute pain disorders among women of reproductive age. Aims: To compare the effects of IV paracetamol with dexketoprofen in patients presenting with primary dysmenorrhea to the emergency department. Study Design: Randomized controlled trial. Methods: Patients over 18 years old presenting with pelvic pain related to menstruation were eligible for the study. Study patients received 1 g paracetamol or 50 mg dexketoprofen in 100 mL normal saline with a 4-5 minute infusion via the intravenous route. Pain intensity was measured by a visual analog scale at 15 and 30 minutes. Patients were randomized and assigned to either of two study arms via sealed envelopes. Study drugs were identical in color, and thus both personnel and patients were blinded to the study drug. The dexketoprofen group comprised 49 patients, and the paracetamol group had 50 patients in the final analysis. Results: The mean age of the study subjects was 20.9±2.5 and the mean duration of the pain was 1.9±1.7 (median: 1, interquartile range: 1 to 2) hours. Both dexketoprofen (median change: 33, 95% CI: 24 to 38) and paracetamol (median change: 21, 95% CI: 12 to 32) effectively reduced the pain at 15 minutes, which was repeated at 30 minutes (median change: 63, 95% CI: 57 to 65 vs 55.5, 95% CI: 50 to 59, respectively). Pain improvement in the dexketoprofen group was better than in the paracetamol group at 15 (median difference: 8, 95% CI: 0 to 16, p=0.048) and 30 (median difference: 6, 95% CI: 1 to 12, p=0.028) minutes, which was statistically significant but not clinically significant. Conclusion: Dexketotoprofen has a better visual analogue scale score that is not clinically relevant compared to paracetamol. © 2018, Galenos Publishing House. All rights reserved. | URI: | https://hdl.handle.net/11499/10935 https://doi.org/10.4274/balkanmedj.2016.0536 |
ISSN: | 2146-3123 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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