Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/20204
Title: Serum Total Homocystein, Folate and Vitamin B12 Levels and their Correlation with Antipsychotic Drug doses in Adult Male Patients with Chronic Schizophrenia
Authors: Eren, E
Yegin, A
Yilmaz, N
Herken, Hasan
Keywords: Antipsychotic drugs; chronic schizophrenia; folic acid;
hyperhomocysteinemia; vitamin B12
Publisher: CLIN LAB PUBL
Abstract: Background: Elevated blood levels of homocysteine (hCY) have been associated with schizophrenic male patients. However, controversy remains regarding the association between lowered plasma folate and vitamin B12, hyperhomocysteinemia, and schizophrenia. Sixty-six (66) male patients with chronic schizophrenia were investigated to test the hypotheses that alterations in Hcy, folate, and vitamin B12 levels might be related to the antipsychotic drug doses used in treatment.
Methods: Serum total homocysteine, folic acid, and vitamin B12 levels were determined by chemiluminescence methods in both patients and control subjects. The patients were grouped according to the antipsychotic drug doses used in their treatment.
Results: Patients had higher homocysteine levels but they did not differ from controls in terms of folate and vitamin B12 levels. On the other hand, only folate levels were negatively correlated in the patient group treated with higher therapeutic doses of chlorpromazine equivalents (>400 mg/day) compared to the patient group with lower doses (<400 mg/day).
Conclusions: Our findings show that higher typical antipsychotic drugs may play a role as modifying factor for folate metabolism in chronic schizoprenic male patients. (Clin. Lab. 2010;56:513-518)
URI: https://hdl.handle.net/11499/20204
ISSN: 1433-6510
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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