Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/23166
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ustundag, S | - |
dc.contributor.author | Dogan, E | - |
dc.contributor.author | Duranay, M | - |
dc.contributor.author | Kazancioglu, R | - |
dc.contributor.author | Celik, V | - |
dc.contributor.author | Unsal, A | - |
dc.contributor.author | Altintepe, L | - |
dc.contributor.author | Dursun, Belda | - |
dc.contributor.author | Akbaş, Ertuğrul | - |
dc.date.accessioned | 2019-08-20T06:50:43Z | - |
dc.date.available | 2019-08-20T06:50:43Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2146-3123 | - |
dc.identifier.uri | https://hdl.handle.net/11499/23166 | - |
dc.identifier.uri | https://doi.org/10.5152/balkanmedj.2016.141173 | - |
dc.description.abstract | Background: We investigated the efficacy, safety and tolerability of once-monthly administration of C.E.R.A. in erythropoiesis stimulating agents (ESAs) naive predialysis patients with CKD for anemia treatment | en_US |
dc.description.abstract | Study Design: Single arm, open label study. | en_US |
dc.description.abstract | Methods: A total of 75 patients (mean (SD) age was 52.8 (16.4) years, 76.0% were female) were included in this study conducted between 12 August 2008 and 30 October 2009 in 9 centers across Turkey. The mean change in Hb concentration (g/dL) between baseline (week 0) and the efficacy evaluation period (EEP) was the primary efficacy parameter evaluated in three consecutive periods including a dose titration period (DTP; with initial 1.2 mu g/kg dose of C.E.R.A., subcutaneously, 28 weeks), EEP (8 weeks) and a long-term safety period (16 weeks). | en_US |
dc.description.abstract | Results: Our analysis revealed an improvement in Hb levels from baseline value of 9.4 (0.4) g/dL to time adjusted average level of 11.4 (0.7) g/dL in EEP in the per protocol (PP) population and from 9.3 (0.5) g/dL to 11.1 (1.0) g/dL in intent-to-treat (ITT) population. Mean (SD) change in Hb levels from baseline to EEP was 2.0 (0.7) g/dl in the PP population (primary endpoint) and 1.7 (1.1) g/dL in the ITT population. The percentage of patients whose Hb concentrations remained within the target range of 10.0-12.0 g/dL throughout the EEP was 43.9% (95% CI: 28.5-60.3%) in the PP population and 38.7% (95% CI: 27.6% to 50.6%) in the ITP population. A total of 206 adverse events (AE) were reported in 77.0% of patients with hypertension (20%) as the most frequent AE. | en_US |
dc.description.abstract | Conclusion: Once-monthly subcutaneous C.E.R.A. administration is effective and safe in the treatment of anemia in pre-dialysis patients with CKD, who are not currently treated with ESAs. | en_US |
dc.language.iso | en | en_US |
dc.publisher | GALENOS YAYINCILIK | en_US |
dc.relation.ispartof | BALKAN MEDICAL JOURNAL | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | CERA; chronic kidney disease; efficacy; hemoglobin levels; safety; | en_US |
dc.subject | tolerability | en_US |
dc.title | Subcutaneous C.E.R.A. for the Treatment of Chronic Renal Anemia in Predialysis Patients | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 322 | en_US |
dc.identifier.endpage | 330 | en_US |
dc.authorid | 0000-0003-3235-0577 | - |
dc.identifier.doi | 10.5152/balkanmedj.2016.141173 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 27308077 | en_US |
dc.identifier.pmid | 27308077 | en_US |
dc.identifier.scopus | 2-s2.0-84971612089 | en_US |
dc.identifier.trdizinid | 238436 | en_US |
dc.identifier.wos | WOS:000379332000011 | en_US |
dc.identifier.wos | WOS:000379332000011 | en_US |
dc.identifier.scopusquality | Q3 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
pdf_BMJ_127.pdf | 438.01 kB | Adobe PDF | View/Open |
CORE Recommender
Page view(s)
22
checked on May 27, 2024
Download(s)
8
checked on May 27, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.