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https://hdl.handle.net/11499/23805
Title: | Determination of Genotoxic Damage by Comet Assay in Smokers | Authors: | Karahan, EG Tomatır, Ayşe Gaye Açıkbaş, İbrahim Er, Ayşen Buket Evyapan, F Akdag, B Arslan, PE |
Keywords: | Genomic Instability; Genotoxicity; Peripheral Blood; Single Cell Gel Electrophoresis; Smoking |
Publisher: | KAMLA-RAJ ENTERPRISES | Abstract: | The clinical course of most diseases related to smoking has a strong relationship with genotoxicity. In this study, the researchers aimed to compare DNA damage of smokers and non-smokers to determine the genotoxic risk. In total, 50 volunteers were included in this study; 30 of them smokers and 20 of them forming the non-smoker control group. Peripheral blood samples taken from the volunteers were deternfined with comet assay. The researchers determined the DNA damage ratio as 12, 75 (7. 14) from smokers 10, 41 (3.41) from nonsmokers (p> 0.05), and also higher DNA damage in male smokers than female ones (p<0. 05). There was no correlation between age and DNA damage. In conclusion, there was no significant difference between smokers and non-smokers.in terms of DNA damage, but there were some important changes in the DNA of smokers and genomic instability was adversely affected. | URI: | https://hdl.handle.net/11499/23805 https://doi.org/10.1080/09723757.2017.1351121 |
ISSN: | 0972-3757 |
Appears in Collections: | Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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