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https://hdl.handle.net/11499/30015
Title: | Oxidative Stress and Genotoxicity in Pterygium: A Systemic Investigation | Authors: | Kılıç Toprak, Emine Toprak, İbrahim Çalışkan, Sadettin Özdemir, Yasin Demirtaş, Önder Altıntaş, Fatih Küçükatay, Vural |
Keywords: | Comet DNA Oxidative stress Pterygium oxidizing agent tantalum thallium titanium antioxidant adult Article clinical article comet assay comparative study controlled study cross-sectional study DNA damage female genotoxicity human male middle aged oxidative stress priority journal prospective study pterygium tail intensity case control study genetics lymphocyte metabolism oxidation reduction reaction pathology physiology Antioxidants Case-Control Studies Comet Assay Cross-Sectional Studies DNA Damage Female Humans Lymphocytes Male Middle Aged Oxidation-Reduction Oxidative Stress Prospective Studies |
Publisher: | Lippincott Williams and Wilkins | Abstract: | Objectives:To perform a systemic investigation on oxidative stress and DNA damage in patients with primary pterygium.Methods:This prospective cross-sectional study included 32 patients with primary pterygium (60.1±2.0 years of age) and 33 age- A nd sex-matched (58.8±2.2 years of age) control subjects (P>0.05). A commercial kit was used for measuring serum total oxidant status (TOS) and total antioxidant status (TAS). The comet assay was performed after lymphocyte isolation from venous blood to quantitate DNA damage. Tail length (TL), tail intensity (TI), and tail moment (TM) were used for statistical analysis as parameters of DNA damage.Results:In the pterygium group, TOS and TAS were significantly higher when compared with those of the control group (P=0.019 and P=0.005, respectively). In terms of DNA damage, patients with pterygium had higher TL, TI, and TM than in the control subjects (P<0.0001 for all).Conclusions:Although current literature focuses on local factors in pterygium pathogenesis, patients with pterygium seem to have increased systemic oxidative status (and compensatory antioxidant response) and genotoxicity, which might create a predisposition for pterygium development. © 2019 Contact Lens Association of Ophthalmologists, Inc. | URI: | https://hdl.handle.net/11499/30015 https://doi.org/10.1097/ICL.0000000000000620 |
ISSN: | 1542-2321 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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