Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30015
Title: Oxidative Stress and Genotoxicity in Pterygium: A Systemic Investigation
Authors: Kılıç Toprak, Emine
Toprak, İbrahim
Çalışkan, Sadettin
Özdemir, Yasin
Demirtaş, Önder
Altıntaş, Fatih
Küçükatay, Vural
Keywords: Comet
DNA
Oxidative stress
Pterygium
oxidizing agent
tantalum
thallium
titanium
antioxidant
adult
Article
clinical article
comet assay
comparative study
controlled study
cross-sectional study
DNA damage
female
genotoxicity
human
male
middle aged
oxidative stress
priority journal
prospective study
pterygium
tail intensity
case control study
genetics
lymphocyte
metabolism
oxidation reduction reaction
pathology
physiology
Antioxidants
Case-Control Studies
Comet Assay
Cross-Sectional Studies
DNA Damage
Female
Humans
Lymphocytes
Male
Middle Aged
Oxidation-Reduction
Oxidative Stress
Prospective Studies
Publisher: Lippincott Williams and Wilkins
Abstract: Objectives:To perform a systemic investigation on oxidative stress and DNA damage in patients with primary pterygium.Methods:This prospective cross-sectional study included 32 patients with primary pterygium (60.1±2.0 years of age) and 33 age- A nd sex-matched (58.8±2.2 years of age) control subjects (P>0.05). A commercial kit was used for measuring serum total oxidant status (TOS) and total antioxidant status (TAS). The comet assay was performed after lymphocyte isolation from venous blood to quantitate DNA damage. Tail length (TL), tail intensity (TI), and tail moment (TM) were used for statistical analysis as parameters of DNA damage.Results:In the pterygium group, TOS and TAS were significantly higher when compared with those of the control group (P=0.019 and P=0.005, respectively). In terms of DNA damage, patients with pterygium had higher TL, TI, and TM than in the control subjects (P<0.0001 for all).Conclusions:Although current literature focuses on local factors in pterygium pathogenesis, patients with pterygium seem to have increased systemic oxidative status (and compensatory antioxidant response) and genotoxicity, which might create a predisposition for pterygium development. © 2019 Contact Lens Association of Ophthalmologists, Inc.
URI: https://hdl.handle.net/11499/30015
https://doi.org/10.1097/ICL.0000000000000620
ISSN: 1542-2321
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

10
checked on Sep 30, 2024

WEB OF SCIENCETM
Citations

10
checked on Sep 16, 2024

Page view(s)

66
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.