Development of molecular imprinted sensor including graphitic carbon nitride/N-doped carbon dots composite for novel recognition of epinephrine

Abstract

The presence of epinephrine is crucial factor relating to several chronic diseases such as hypertension and myocardial infarction. Due to these significant problems, electrochemical recognition based on graphitic carbon nitride/N-doped carbon dots composite (g-C3N4/NCDS) and molecularly imprinted polymer was presented for epinephrine detection in this study. Fourier-transform infrared spectroscopy, scanning electron microscope, transmission electron microscope, x-ray diffraction method and electroanalytical methods such as electrochemical impedance spectroscopy and cyclic voltammetry were performed for characterizations of nanomaterials. After that, epinephrine imprinted voltammetric sensor on graphitic carbon nitride/N-doped carbon dots composite was carried out in presence of 100.0 mM pyrrole containing 25.0 mM epinephrine via cyclic voltammetry. Epinephrine imprinted electrode showed high sensitivity for epinephrine recognition in wide linear range of 1.0 × 10-12 - 1.0 × 10-9 M and detection limit (LOD) of 3.0 × 10-13 M. Epinephrine imprinted sensor was applied to urine samples for epinephrine analysis. © 2019 Elsevier Ltd