Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30033
Title: Investigation the effect of Hypericum perforatum on corneal alkali burns
Authors: Yılmaz, Uğur
Kaya, Hüseyin
Turan, Murat
Bir, Ferda
Şahin, Barbaros
Keywords: Corneal alkali burn
corneal fibroblastic activity
corneal inflammation
corneal vascularization
Hypericum perforatum
olive oil
Hypericum perforatum extract
antiinflammatory agent
plant extract
animal experiment
animal model
Article
caustic burn
cell differentiation
comparative effectiveness
controlled study
cornea burn
cornea neovascularization
drug synthesis
female
general anesthesia
keratitis
nonhuman
rat
topical treatment
treatment duration
animal
chemical burn
drug effect
eye burn
fibroblast
Hypericum
pathology
Wistar rat
Animals
Anti-Inflammatory Agents
Burns, Chemical
Corneal Neovascularization
Eye Burns
Female
Fibroblasts
Plant Extracts
Rats, Wistar
Publisher: Taylor and Francis Ltd
Abstract: Purpose: To investigate the effect of Hypericum perforatum on corneal alkali burn. Methods: We studied 45 250 g weighing, 4 months old Wistar albino rats. Alkaline burns were performed in the corneas of all experimental animals with 2 mol/L NaOH after general anaesthesia. Rats were divided into five groups according to the subsequent process applied to them: group 1 was the topical Hypericum perforatum group, group 2 was the topical pure olive oil group, group 3 was the oral Hypericum perforatum group, group 4 was the oral pure olive oil group, and group 5 was the control untreated group. Rats were sacrificed under general anaesthesia on the 14 day. The rate of corneal inflammation, neovascularization, fibroblastic activity, and cluster of differentiation 31 (CD31) staining was investigated. Result: There were 45 rats at the beginning of the study. One rat in groups 1, 2, and 3 died during the study; therefore, 42 rats could be evaluated. There were 8 rats in group 1, 8 rats in group 2, 8 rats in group 3, and 9 rats in group 4. We found less corneal neovascularization (CNV), inflammation, and fibroblastic activity in group 1 and group 2 than in the other groups (p ? 0.001 for all parameters). CNV, inflammation, fibroblastic activity, and CD31 staining rates were lower in group 1 than in group 2 (p ? 0.001 for all parameters). There was no difference between groups 3, 4, and 5 (respectively, p = 0.436, 0.634, and 0.750). Conclusions: We found that both topical Hypericum perforatum oily extract and olive oil have anti-inflammatory, anti-angiogenic, and anti-fibroblastic effects when applied after corneal alkali burns in rat corneas. Further studies should be conducted in this field. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
URI: https://hdl.handle.net/11499/30033
https://doi.org/10.1080/15569527.2019.1622560
ISSN: 1556-9527
Appears in Collections:Acıpayam Meslek Yüksekokulu Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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