Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30083
Title: Increased expression of pentraxin 3 in placental tissues from patients with unexplained recurrent pregnancy loss
Authors: Zeybek, S.
Tepeli, E.
Çetin, Gökhan Ozan
Caner, Vildan
Şenol, Hande
Yildirim, B.
Bağcı, Gülseren
Keywords: Inflammation
Pentraxin 3 (PTX3)
Placentai expression
Real-time polymerase chain reaction (RT-PCR)
Unexplained recurrent pregnancy loss (URPL)
messenger RNA
pentraxin 3
Article
clinical article
controlled study
female
fetus
gestational age
human
human tissue
immunohistochemistry
live birth
maternal age
medically unexplained symptom
placenta tissue
protein expression
protein expression level
real time polymerase chain reaction
recurrent abortion
Publisher: Sciendo
Abstract: Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a evolutionarily conserved multimeric pattern recognition receptor involved in the humoral component of the innate immune system. Pentraxin 3 is released when tissue is stressed or damaged, and interacts with many different ligands. Pentraxin 3 exerts a pivotal role both as a regulator and as an indicator of inflammatory response in the pathogenesis of many diseases such as sepsis, vasculitis and preeclampsia. Uncontrolled inflammatory response is considered a major cause of unexplained recurrent pregnancy loss (URPL). We determined the PTX3 messenger ribonucleic acid (mRnA) and protein expression levels in placentai tissues from 50 women with URPL, and made comparison with those in 50 age-matched control subjects. In quantitative real-time polymerase chain reaction (qRT-PcR) and immunohistochemistry analyses, PTX3 mRnA and protein levels, respectively, were significantly increased in URPL patients compared with their respective controls (p = 0.0001). Although no significant correlations were identified between PTX3 expression levels and clinical parameters such as maternal age, numbers of previous pregnancy losses, and gestational age at miscarriage, PTX3 mRnA expression was significantly higher in patients with no live births than in women with previous live births (p = 0.0001). Our study suggests that tissue-specific expression of PTX3 is associated with URPL. Further larger studies are required to determine whether PTX3 expression can be used as a biomarker to manage URPL in routine clinical practice. © 2019 zeybek S, Tepeli E, cetin GO, caner V, Senol H, Yildirim B, Bagci G, published by Sciendo 2019.
URI: https://hdl.handle.net/11499/30083
https://doi.org/10.2478/bjmg-2019-0002
ISSN: 1311-0160
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

7
checked on Dec 7, 2024

WEB OF SCIENCETM
Citations

6
checked on Dec 11, 2024

Page view(s)

54
checked on Aug 24, 2024

Download(s)

46
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.