Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30106
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAydin, S.U.-
dc.contributor.authorKabukçu Başay, Bürge-
dc.contributor.authorÇetin, Gökhan Ozan-
dc.contributor.authorGüngör Aydın, Ayşegül-
dc.contributor.authorTepeli, E.-
dc.date.accessioned2020-06-08T12:11:14Z
dc.date.available2020-06-08T12:11:14Z
dc.date.issued2019-
dc.identifier.issn0022-3956-
dc.identifier.urihttps://hdl.handle.net/11499/30106-
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2019.05.021-
dc.description.abstractAttention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Its etiology is not clearly understood yet, but neurobiological, genetic and environmental factors are shown to play a role. The relationship between ADHD and miRNAs has been studied quite recently, and few studies have been conducted up to now. In this study, peripheral blood expression levels of miR-5692b, miR-let-7d, miR-124-3p, miR-4447 and miR-107 of 30 children and adolescents with combined type ADHD were compared to 30 healthy controls to understand the roles of these miRNAs in the ADHD etiopathogenesis. Compared to controls, levels of miR-5692b (p = 0.006) were found higher and levels of miR-let-7d (p = 0.017) were found lower in the ADHD group. There was no significant difference in terms of miR-124-3p, miR-4447, and miR-107 levels between the groups. In conclusion, our findings support other studies suggesting the importance of miRNAs in the pathogenesis of ADHD. Regarding the regulatory role of miRNAs in gene regulation, their contribution to etiopathogenesis and heterogeneity of ADHD should be investigated further. © 2019 Elsevier Ltden_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdolescenten_US
dc.subjectAttention deficit hyperactivity disorderen_US
dc.subjectChildrenen_US
dc.subjectGeneticsen_US
dc.subjectMicro RNAen_US
dc.subjectPsychiatryen_US
dc.subjectmicroRNAen_US
dc.subjectmicroRNA 107en_US
dc.subjectmicroRNA 124 3pen_US
dc.subjectmicroRNA 4447en_US
dc.subjectmicrorna 5692ben_US
dc.subjectmicrorna let 7den_US
dc.subjectunclassified drugen_US
dc.subjectadolescenten_US
dc.subjectArticleen_US
dc.subjectattention deficit disorderen_US
dc.subjectchilden_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectfemaleen_US
dc.subjecthumanen_US
dc.subjectmaleen_US
dc.subjectpriority journalen_US
dc.subjectreal time polymerase chain reactionen_US
dc.subjectreverse transcription polymerase chain reactionen_US
dc.titleAltered microRNA 5692b and microRNA let-7d expression levels in children and adolescents with attention deficit hyperactivity disorderen_US
dc.typeArticleen_US
dc.identifier.volume115en_US
dc.identifier.startpage158
dc.identifier.startpage158en_US
dc.identifier.endpage164en_US
dc.authorid0000-0003-3398-7959-
dc.identifier.doi10.1016/j.jpsychires.2019.05.021-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid31146084en_US
dc.identifier.scopus2-s2.0-85066425601en_US
dc.identifier.wosWOS:000472245500019en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

13
checked on Dec 21, 2024

WEB OF SCIENCETM
Citations

11
checked on Dec 20, 2024

Page view(s)

40
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.