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https://hdl.handle.net/11499/30106
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Aydin, S.U. | - |
dc.contributor.author | Kabukçu Başay, Bürge | - |
dc.contributor.author | Çetin, Gökhan Ozan | - |
dc.contributor.author | Güngör Aydın, Ayşegül | - |
dc.contributor.author | Tepeli, E. | - |
dc.date.accessioned | 2020-06-08T12:11:14Z | |
dc.date.available | 2020-06-08T12:11:14Z | |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0022-3956 | - |
dc.identifier.uri | https://hdl.handle.net/11499/30106 | - |
dc.identifier.uri | https://doi.org/10.1016/j.jpsychires.2019.05.021 | - |
dc.description.abstract | Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Its etiology is not clearly understood yet, but neurobiological, genetic and environmental factors are shown to play a role. The relationship between ADHD and miRNAs has been studied quite recently, and few studies have been conducted up to now. In this study, peripheral blood expression levels of miR-5692b, miR-let-7d, miR-124-3p, miR-4447 and miR-107 of 30 children and adolescents with combined type ADHD were compared to 30 healthy controls to understand the roles of these miRNAs in the ADHD etiopathogenesis. Compared to controls, levels of miR-5692b (p = 0.006) were found higher and levels of miR-let-7d (p = 0.017) were found lower in the ADHD group. There was no significant difference in terms of miR-124-3p, miR-4447, and miR-107 levels between the groups. In conclusion, our findings support other studies suggesting the importance of miRNAs in the pathogenesis of ADHD. Regarding the regulatory role of miRNAs in gene regulation, their contribution to etiopathogenesis and heterogeneity of ADHD should be investigated further. © 2019 Elsevier Ltd | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Ltd | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Adolescent | en_US |
dc.subject | Attention deficit hyperactivity disorder | en_US |
dc.subject | Children | en_US |
dc.subject | Genetics | en_US |
dc.subject | Micro RNA | en_US |
dc.subject | Psychiatry | en_US |
dc.subject | microRNA | en_US |
dc.subject | microRNA 107 | en_US |
dc.subject | microRNA 124 3p | en_US |
dc.subject | microRNA 4447 | en_US |
dc.subject | microrna 5692b | en_US |
dc.subject | microrna let 7d | en_US |
dc.subject | unclassified drug | en_US |
dc.subject | adolescent | en_US |
dc.subject | Article | en_US |
dc.subject | attention deficit disorder | en_US |
dc.subject | child | en_US |
dc.subject | clinical article | en_US |
dc.subject | controlled study | en_US |
dc.subject | female | en_US |
dc.subject | human | en_US |
dc.subject | male | en_US |
dc.subject | priority journal | en_US |
dc.subject | real time polymerase chain reaction | en_US |
dc.subject | reverse transcription polymerase chain reaction | en_US |
dc.title | Altered microRNA 5692b and microRNA let-7d expression levels in children and adolescents with attention deficit hyperactivity disorder | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 115 | en_US |
dc.identifier.startpage | 158 | |
dc.identifier.startpage | 158 | en_US |
dc.identifier.endpage | 164 | en_US |
dc.authorid | 0000-0003-3398-7959 | - |
dc.identifier.doi | 10.1016/j.jpsychires.2019.05.021 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 31146084 | en_US |
dc.identifier.scopus | 2-s2.0-85066425601 | en_US |
dc.identifier.wos | WOS:000472245500019 | en_US |
dc.identifier.scopusquality | Q1 | - |
dc.owner | Pamukkale University | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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