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https://hdl.handle.net/11499/30111
Title: | The Antibiotic sensitivity of Stenotrophomonas maltophilia in a 5-year period and investigation of clonal outbreak with PFGE | Authors: | Çalışkan, Ahmet Çopur Çicek, A. Aydogan Ejder, N. Karagöz, A. Kirişci, Ö. Kılıç, S. |
Keywords: | antibiotic sensitivity clonal outbreak PFGE Pulsed Field Gel Electrophoresis |
Publisher: | NLM (Medline) | Abstract: | INTRODUCTION: Stenotrophomonas maltophilia, which is able to form a biofilm, has mostly been related to catheters when it is the agent in hospital infections; these infections generally present as bacteremia and pneumonia, which may progress with complications and result in death. METHODOLOGY: The study included 153 S. maltophilia strains isolated from clinical samples sent to our hospital laboratory between 1 January 2014 and 30 June 2018. The bacteria were identified and their antibiotic sensitivity was determined using the VITEK-2 automated system. PFGE (Pulsed Field Gel Electrophoresis): The strains isolated from 34 patient clinical samples and from 1 patient bedcover were taken for PFGE examination. RESULTS: The TMP/SXT and levofloxacin sensitivity of 153 S. maltophilia strains was examined. TMP/SXT resistance was determined to be 39% and levofloxacin resistance at 5%. Among 35 S. maltophilia strains, seven genotypes were identified using the PFGE method. While three strains showed a specific genotype profile, the other 32 were determined to consist of four clusters. The cluster rate was therefore 91.4% (32/35). CONCLUSIONS: There was a clonal relationship between the vast majority of the 35 S. maltophilia isolates, which suggests that there was a cross-contamination problem in the hospital. One strain (#4) was identified by dendrogram analysis showed a high rate of similarity to the other strains and was determined to be the common source of the cross-contamination. Copyright (c) 2019 Ahemr Caliksan, Aysegul Copur Cicek, Nebahat Aydogan Ejder, Alper Karagoz, Ozlem Kirisci, Selcuk Kilic. | URI: | https://hdl.handle.net/11499/30111 https://doi.org/10.3855/jidc.11171 |
ISSN: | 1972-2680 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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11171-Article Text-87592-1-10-20190902 (1).pdf | 1.23 MB | Adobe PDF | View/Open |
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