Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30131
Title: Impaired Blood Rheology in Pulmonary Arterial Hypertension
Authors: Yaylalı, Yalın Tolga
Kılıç-Toprak, Emine
Özdemir, Yasin
Şenol, Hande
Bor-Küçükatay, Melek
Keywords: Blood rheology
Erythrocyte aggregation
Erythrocyte deformability
Pulmonary arterial hypertension
amino terminal pro brain natriuretic peptide
fibrinogen
biological marker
brain natriuretic peptide
peptide fragment
pro-brain natriuretic peptide (1-76)
adult
Article
blood rheology
cardiac index
clinical article
controlled study
erythrocyte aggregation
erythrocyte deformability
female
heart right atrium pressure
human
lung vascular resistance
male
oxygen saturation
priority journal
prospective study
pulmonary hypertension
six minute walk test
aged
blood
clinical trial
heart catheterization
middle aged
multicenter study
pathophysiology
vascular resistance
Aged
Biomarkers
Cardiac Catheterization
Female
Humans
Hypertension, Pulmonary
Male
Middle Aged
Natriuretic Peptide, Brain
Peptide Fragments
Vascular Resistance
Publisher: Elsevier Ltd
Abstract: Background: Understanding of the pathophysiologic manifestations of pulmonary arterial hypertension (PAH) is still evolving. The aims of the present study were to determine the alterations in blood rheology, and to investigate the relationship between those alterations and laboratory parameters in PAH. Methods: The study included 21 consecutive treatment-naive patients with PAH and 32 age and sex-matched healthy controls. Patients were categorised in class II (n = 6), class III (n = 13), and class IV (n = 2). All subjects underwent right-heart catheterisation. Erythrocyte deformability and aggregation were measured by an ektacytometer. Results: Haemodynamic variables were as follows: the mean right atrial pressure: 9.94 ± 5.76 mmHg; the average pulmonary vascular resistance: 5.66 ± 3 WU; Fick cardiac index: 4.15 ± 2.75 l/min/m2; and mixed venous O2 saturation: 64.59 ± 12.53%. The average 6-minute walk distance was 351.09 ± 133.08 m. Erythrocyte deformability measured at 0.95, 3.00, and 5.33 Pa was significantly lower, erythrocyte aggregation index (AI) was higher, and aggregation half-time (t1/2) was lower in PAH. AI and fibrinogen were positively correlated with NT pro-BNP (AI-NT pro-BNP: r = 0.579; fibrinogen-NT pro-BNP: r = 0.591). t1/2 was negatively correlated with NT pro-BNP (t1/2-NT pro-BNP: r = -0.648). Conclusions: The increase in erythrocyte aggregation and the decrease in deformability may theoretically increase the flow resistance and may be of haemodynamic significance. The association between erythrocyte aggregation and NT pro-BNP may indicate that erythrocyte aggregation increases with disease progression. These alterations contribute to the understanding of the pathophysiology and could serve as markers of disease presence. © 2018 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ)
URI: https://hdl.handle.net/11499/30131
https://doi.org/10.1016/j.hlc.2018.07.014
ISSN: 1443-9506
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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