Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30137
Title: The effects of type I collagen on bone defects and gene expression changes for osteogenesis: In a rat model
Authors: Yiğiter, Özgür
Yörükoğlu, Ali Çağdaş
Şentürk, Nilay
Dodurga, Yavuz
Demirkan, Ahmet Fahir
Keywords: bone defects
bone morphogenic protein
gene expression
osteogenesis
type I collagen
bone morphogenetic protein 2
bone morphogenetic protein 4
bone morphogenetic protein 5
bone morphogenetic protein 6
bone morphogenetic protein receptor 1A
bone morphogenetic protein receptor 1B
bone morphogenetic protein receptor 2
chrd protein
collagen type 1
cyclin dependent kinase inhibitor 1A
cytokine
growth differentiation factor 5
inhibitor of differentiation 1
interleukin 6
messenger RNA
osteogenic protein 1
osteogenin
platelet derived growth factor
procollagen C proteinase
protein c fos
protein Eng
serpine 1
Smad1 protein
somatomedin C
transforming growth factor beta receptor 1
transforming growth factor beta receptor 2
unclassified drug
animal experiment
animal model
animal tissue
Article
bone defect
bone development
connective tissue
controlled study
electronystagmography
female
femur
foreign body reaction
fracture healing
histopathology
inflammation
nonhuman
ossification
priority journal
rat
Publisher: Wiley-Liss Inc.
Abstract: The aim of this study is to investigate the effects of type I collagen on bone defects and on genes specifically for osteogenesis in a rat model. Two millimeter drill hole bone defect was created in the femur of rats. In the experimental group, type I collagen was applied in bone defects whereas in control group defects were left empty. Inflammation, development of connective tissue, osteogenesis, and foreign body reaction parameters evaluated with histologically and genes evaluated by blood samples. In the experimental group, the histopathologically significant change was found in favor of bone healing only at the first week. A significant increase was found in genetic expressions of BMP-1, 2, 3, 4, 5, 6, 7, TGF-ßRII, Smad-1, IL-6, BMPR-IA, BMPR-IB, Eng, BMPR-II, c-fos, Cdkn1a, Chrd, Gdf-5, Id-1, PDGF-ß, IGF-1, Serpine-1, and TGF-ßRI at the first hour. At the first, third, and sixth week, no significant increase was found in any of the gene expressions. Type I collagen is found to be effective in favor of bone healing through increased inflammatory cytokines and expression of BMP genes in the early stages of fracture healing. © 2019 Wiley Periodicals, Inc.
URI: https://hdl.handle.net/11499/30137
https://doi.org/10.1002/jcb.28432
ISSN: 0730-2312
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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