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https://hdl.handle.net/11499/30137
Title: | The effects of type I collagen on bone defects and gene expression changes for osteogenesis: In a rat model | Authors: | Yiğiter, Özgür Yörükoğlu, Ali Çağdaş Şentürk, Nilay Dodurga, Yavuz Demirkan, Ahmet Fahir |
Keywords: | bone defects bone morphogenic protein gene expression osteogenesis type I collagen bone morphogenetic protein 2 bone morphogenetic protein 4 bone morphogenetic protein 5 bone morphogenetic protein 6 bone morphogenetic protein receptor 1A bone morphogenetic protein receptor 1B bone morphogenetic protein receptor 2 chrd protein collagen type 1 cyclin dependent kinase inhibitor 1A cytokine growth differentiation factor 5 inhibitor of differentiation 1 interleukin 6 messenger RNA osteogenic protein 1 osteogenin platelet derived growth factor procollagen C proteinase protein c fos protein Eng serpine 1 Smad1 protein somatomedin C transforming growth factor beta receptor 1 transforming growth factor beta receptor 2 unclassified drug animal experiment animal model animal tissue Article bone defect bone development connective tissue controlled study electronystagmography female femur foreign body reaction fracture healing histopathology inflammation nonhuman ossification priority journal rat |
Publisher: | Wiley-Liss Inc. | Abstract: | The aim of this study is to investigate the effects of type I collagen on bone defects and on genes specifically for osteogenesis in a rat model. Two millimeter drill hole bone defect was created in the femur of rats. In the experimental group, type I collagen was applied in bone defects whereas in control group defects were left empty. Inflammation, development of connective tissue, osteogenesis, and foreign body reaction parameters evaluated with histologically and genes evaluated by blood samples. In the experimental group, the histopathologically significant change was found in favor of bone healing only at the first week. A significant increase was found in genetic expressions of BMP-1, 2, 3, 4, 5, 6, 7, TGF-ßRII, Smad-1, IL-6, BMPR-IA, BMPR-IB, Eng, BMPR-II, c-fos, Cdkn1a, Chrd, Gdf-5, Id-1, PDGF-ß, IGF-1, Serpine-1, and TGF-ßRI at the first hour. At the first, third, and sixth week, no significant increase was found in any of the gene expressions. Type I collagen is found to be effective in favor of bone healing through increased inflammatory cytokines and expression of BMP genes in the early stages of fracture healing. © 2019 Wiley Periodicals, Inc. | URI: | https://hdl.handle.net/11499/30137 https://doi.org/10.1002/jcb.28432 |
ISSN: | 0730-2312 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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