Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30162
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dc.contributor.authorSoliman, A.A.-
dc.contributor.authorAttaby, F.A.-
dc.contributor.authorAlajrawy, O.I.-
dc.contributor.authorMajeed, S.R.-
dc.contributor.authorŞahin, Çiğdem-
dc.contributor.authorVarlikli, C.-
dc.date.accessioned2020-06-08T12:11:30Z
dc.date.available2020-06-08T12:11:30Z
dc.date.issued2019-
dc.identifier.issn0036-0236-
dc.identifier.urihttps://hdl.handle.net/11499/30162-
dc.identifier.urihttps://doi.org/10.1134/S0036023619060020-
dc.description.abstractNew water soluble Ru(II) binary complex [Ru(C5H7N3)(X)(H2O)2] with 2-hydrazinopyridine and its ternary complexes with X = dichloride, oxalate, malonate or pyrophosphate ligands have been synthesized. The complexes have been characterized using elemental analyses, mass, IR, and UV-Vis. spectroscopies, cyclic voltammetry, magnetic susceptibility, and thermal analysis. The complexes are diamagnetic and the electronic spectral data showed that peaks are due to low spin octahedral Ru(II) complexes. The optimized structures of the complexes 1–4 indicate distorted octahedral geometry with bond angles around the ruthenium atom ranged from 80.44° to 99.64°. The values of the electronic energies (-635 to -1145 a.u.), the highest occupied molecular orbital energies (-0.181 to 0.073 a.u.) and lowest unoccupied molecular orbital energies (-0.056 to 0.167 a.u.) indicate the stability of the complexes. The complexes are polarized as indicated from the dipole moment values (9.39–14.27 Debye). The complexes have noticeable cytotoxicity with IC50 (µM): 0.011–0.062 (HepG-2), 0.015–0.080 (MCF-7), 0.015–0.116 (HCT-116), and PC-3 (0.034–0.125). © 2019, Pleiades Publishing, Ltd.en_US
dc.language.isoenen_US
dc.publisherPleiades Publishingen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2-hydrazinopyridineen_US
dc.subjectantitumor complexesen_US
dc.subjectCytotoxicityen_US
dc.subjectDFT calculationsen_US
dc.subjectRu(II) complexesen_US
dc.subjectCyclic voltammetryen_US
dc.subjectMagnetic susceptibilityen_US
dc.subjectMolecular orbitalsen_US
dc.subjectSynthesis (chemical)en_US
dc.subjectThermoanalysisen_US
dc.subjectAnti-tumorsen_US
dc.subjectDFT calculationen_US
dc.subjectElectronic spectral dataen_US
dc.subjectHighest occupied molecular orbitalen_US
dc.subjectLowest unoccupied molecular orbitalen_US
dc.subjectOptimized structuresen_US
dc.subjectRu complexesen_US
dc.subjectRuthenium compoundsen_US
dc.titleSoluble Cytotoxic Ruthenium(II) Complexes with 2-Hydrazinopyridineen_US
dc.typeArticleen_US
dc.identifier.volume64en_US
dc.identifier.issue6en_US
dc.identifier.startpage742
dc.identifier.startpage742en_US
dc.identifier.endpage754en_US
dc.identifier.doi10.1134/S0036023619060020-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-85068788808en_US
dc.identifier.wosWOS:000474448400009en_US
dc.identifier.scopusqualityQ3-
dc.ownerPamukkale University-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
crisitem.author.dept14.01. Surgical Medicine-
Appears in Collections:Fen-Edebiyat Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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